Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 13/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8065956 | 1.00 | HSD11B1 (0.59) | HSD11B1EPHX2EPHX1HSD11B2CNR1 | |
| SCHEMBL4540405 | 0.95 | HSD11B1 (0.56) | HSD11B1EPHX2EPHX1HSD11B2 | |
| SCHEMBL8061511 | 0.95 | HSD11B1 (0.62) | HSD11B1EPHX2EPHX1HSD11B2CNR1 | |
| SCHEMBL4538124 | 0.95 | HSD11B1 (0.62) | HSD11B1EPHX2EPHX1HSD11B2CNR1 | |
| SCHEMBL8070996 | 0.90 | HDAC3 (0.52) | HSD11B1EPHX2EPHX1HDAC3HDAC4 | |
| SCHEMBL4535493 | 0.90 | HDAC3 (0.52) | HSD11B1EPHX2EPHX1HDAC3HDAC4 | |
| SCHEMBL8058685 | 0.87 | HSD11B1 (0.49) | HSD11B1EPHX2HSD11B2 | |
| SCHEMBL4539129 | 0.86 | EPHX2 (0.52) | HSD11B1EPHX2EPHX1CNR1CNR2 | |
| SCHEMBL4539701 | 0.86 | HDAC3 (0.47) | HSD11B1EPHX2EPHX1HDAC3HDAC4 | |
| SCHEMBL4539839 | 0.85 | HDAC3 (0.54) | HSD11B1EPHX2EPHX1HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |