SCHEMBL4539839

SCHEMBL4539839

O=C(CC1CCN(S(=O)(=O)c2ccccc2Cl)CC1)NC12CC3CC(CC(C3)C1)C2

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.54
HDAC4 P56524 1/20 0.54
HDAC1 Q13547 1/20 0.54
HDAC7 Q8WUI4 1/20 0.54
HDAC2 Q92769 1/20 0.54
HDAC10 Q969S8 1/20 0.54
HDAC11 Q96DB2 1/20 0.54
HDAC8 Q9BY41 1/20 0.54
HDAC6 Q9UBN7 1/20 0.54
HDAC9 Q9UKV0 1/20 0.54
HDAC5 Q9UQL6 1/20 0.54
EPHX1 P07099 4/20 0.53
FAAH O00519 5/20 0.50
EPHX2 P34913 4/20 0.50
HSD11B1 P28845 1/20 0.50
LMNA P02545 1/20 0.47
TSHR P16473 1/20 0.47
ALOX12 P18054 1/20 0.47
HTT P42858 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4535493 0.95 HDAC3 (0.52) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL8070996 0.95 HDAC3 (0.52) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL4539701 0.90 HDAC3 (0.47) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL8061511 0.90 HSD11B1 (0.62) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL4538124 0.90 HSD11B1 (0.62) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL4539947 0.88 EPHX2 (0.57) EPHX1EPHX2HSD11B1LMNAPSMB5
SCHEMBL4533128 0.87 EPHX1 (0.51) EPHX1EPHX2HSD11B1LMNATSHR
SCHEMBL8066091 0.85 KMT2A (0.51) EPHX1EPHX2LMNARAB9AKMT2A
SCHEMBL4537222 0.85 KMT2A (0.51) EPHX1EPHX2LMNARAB9AKMT2A
SCHEMBL4542094 0.85 NPC1 (0.57) HDAC3HDAC4HDAC1HDAC7HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009070497-A1 SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE SMITHKLINE BEECHAM CORPORATION (US) 2009-06-04 WO claimed
WO-2009070497-A1 SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE SMITHKLINE BEECHAM CORPORATION (US) 2009-06-04 WO disclosed