Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CIT | O14578 | 1/20 | 0.61 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.47 |
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.45 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.45 |
| ▸ | PRKACA | P17612 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | GSK3A | P49840 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | PRKX | P51817 | 2/20 | 0.45 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.45 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.45 |
| ▸ | SGK2 | Q9HBY8 | 2/20 | 0.45 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.45 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.45 |
| ▸ | ALPI | P09923 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16669850 | 0.85 | ALPI (0.58) | CITALPIPKMPTGS1XIAP | |
| SCHEMBL16669849 | 0.85 | ALPI (0.58) | CITALPIPKMPTGS1XIAP | |
| SCHEMBL4518611 | 0.84 | GPR142 (0.46) | CITGPR88GPR142ROCK2ROCK1 | |
| SCHEMBL18180135 | 0.79 | CIT (0.52) | CITMAPK1ALPIPKMPTGS1 | |
| SCHEMBL16669866 | 0.79 | CIT (0.52) | CITMAPK1ALPIPKMPTGS1 | |
| SCHEMBL30659096 | 0.79 | CIT (0.52) | CITMAPK1ALPIPKMPTGS1 | |
| SCHEMBL16669867 | 0.79 | CIT (0.52) | CITMAPK1ALPIPKMPTGS1 | |
| SCHEMBL19962116 | 0.79 | CIT (0.52) | CITGPR88ALPIPKMPTGS1 | |
| SCHEMBL4533605 | 0.78 | MAPT (0.48) | GPR88GPR142ROCK2ROCK1RPS6KA5 | |
| SCHEMBL4520248 | 0.78 | CIT (0.43) | CITGPR88GPR142ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8211919-B2 | Amide derivatives as rock inhibitors | ASTELLAS PHARMA INC. (JP) | 2012-07-03 | — | — | US | disclosed |
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ROCK1, ROCK2, RHOA | CIT 7/4885GPR88 1449/4885GPR142 3166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.