Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.98 |
| ▸ | MAPT | P10636 | 3/20 | 0.98 |
| ▸ | LMNA | P02545 | 2/20 | 0.98 |
| ▸ | HPGD | P15428 | 1/20 | 0.98 |
| ▸ | MEN1 | O00255 | 5/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.81 |
| ▸ | POLB | P06746 | 2/20 | 0.81 |
| ▸ | TSHR | P16473 | 2/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.77 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.77 |
| ▸ | USP2 | O75604 | 1/20 | 0.77 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.77 |
| ▸ | HTT | P42858 | 1/20 | 0.77 |
| ▸ | GFER | P55789 | 1/20 | 0.77 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.77 |
| ▸ | NPC1 | O15118 | 2/20 | 0.69 |
| ▸ | MMP9 | P14780 | 1/20 | 0.68 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5438395 | 0.90 | ALDH1A1 (0.81) | GAAALDH1A1MAPTLMNAHPGD | |
| SCHEMBL4518527 | 0.90 | MEN1 (1.00) | GAAALDH1A1MAPTLMNAHPGD | |
| SCHEMBL4533989 | 0.89 | MEN1 (0.89) | GAAALDH1A1MAPTLMNAHPGD | |
| SCHEMBL4160940 | 0.89 | ALDH1A1 (0.78) | GAAALDH1A1MAPTLMNAHPGD | |
| SCHEMBL4529453 | 0.89 | ALDH1A1 (0.78) | GAAALDH1A1MAPTLMNAHPGD | |
| SCHEMBL4526537 | 0.88 | MEN1 (0.98) | GAAALDH1A1MAPTLMNAHPGD | |
| SCHEMBL4519779 | 0.88 | MEN1 (0.79) | GAAALDH1A1MAPTLMNAHPGD | |
| SCHEMBL3608656 | 0.87 | MAPT (0.76) | GAAALDH1A1MAPTLMNAHPGD | |
| SCHEMBL4526089 | 0.87 | MEN1 (0.85) | GAAALDH1A1MAPTLMNAHPGD | |
| SCHEMBL4514872 | 0.87 | MEN1 (0.85) | GAAALDH1A1MAPTLMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3811940-B1 | SUBSTITUTED 4,5'-BITHIAZOLES AS INHIBITORS OF THE HUMAN DNA TOPOISOMERASE II | KEMIJSKI INST (SI) | 2023-05-10 | — | — | EP | claimed |
| EP-3811940-A1 | SUBSTITUTED 4,5'-BITHIAZOLES AS INHIBITORS OF THE HUMAN DNA TOPOISOMERASE II | Kemijski Institut (SI) | 2021-04-28 | — | — | EP | claimed |
| US-20090029998-A1 | Thiazole Derivatives and Use Thereof | APPLIED RESEARCH SYSTEM ARS HOLDING N.V. (NL) | 2009-01-29 | — | — | US | claimed |
| EP-1709019-B1 | THIAZOLE DERIVATIVES AND USE THEREOF | APPLIED RESEARCH SYSTEMS (AN) | 2007-08-08 | — | — | EP | claimed |
| EP-3811940-B1 | SUBSTITUTED 4,5'-BITHIAZOLES AS INHIBITORS OF THE HUMAN DNA TOPOISOMERASE II | KEMIJSKI INST (SI) | 2023-05-10 | — | — | EP | disclosed |
| EP-3811940-A1 | SUBSTITUTED 4,5'-BITHIAZOLES AS INHIBITORS OF THE HUMAN DNA TOPOISOMERASE II | Kemijski Institut (SI) | 2021-04-28 | — | — | EP | disclosed |
| US-9198914-B2 | Methods and compositions for modulating RAD51 and homologous recombination | THE UNIVERSITY OF CHICAGO (US) | 2015-12-01 | — | — | US | disclosed |
| US-9150561-B2 | Thiazole derivatives and use thereof | MERCK SERONO S.A. (CH) | 2015-10-06 | — | — | US | disclosed |
| US-9150561-B2 | Thiazole derivatives and use thereof | MERCK SERONO S.A. (CH) | 2015-10-06 | — | — | US | disclosed |
| US-20140228365-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | MERCK SERONO S.A. (CH) | 2014-08-14 | — | — | US | disclosed |
| US-20140228365-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | MERCK SERONO S.A. (CH) | 2014-08-14 | — | — | US | disclosed |
| US-20140228365-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | MERCK SERONO S.A. (CH) | 2014-08-14 | — | — | US | disclosed |
| US-8802861-B2 | Thiazole derivatives and use thereof | MERCK SERONO SA (CH) | 2014-08-12 | — | — | US | disclosed |
| US-8802861-B2 | Thiazole derivatives and use thereof | MERCK SERONO SA (CH) | 2014-08-12 | — | — | US | disclosed |
| US-8802861-B2 | Thiazole derivatives and use thereof | MERCK SERONO SA (CH) | 2014-08-12 | — | — | US | disclosed |
| US-20140142103-A1 | Methods and Compositions for Modulating Rad51 and Homologous Recombination | THE UNIVERSITY OF CHICAGO (US) | 2014-05-22 | — | — | US | disclosed |
| US-20100248371-A1 | METHODS AND COMPOSITIONS FOR MODULATING RAD51 AND HOMOLOGOUS RECOMBINATION | UNIVERSITY OF CHICAGO (US) | 2010-09-30 | — | — | US | disclosed |
| US-20090029998-A1 | Thiazole Derivatives and Use Thereof | APPLIED RESEARCH SYSTEM ARS HOLDING N.V. (NL) | 2009-01-29 | — | — | US | disclosed |
| US-20090029998-A1 | Thiazole Derivatives and Use Thereof | APPLIED RESEARCH SYSTEM ARS HOLDING N.V. (NL) | 2009-01-29 | — | — | US | disclosed |
| US-20090029998-A1 | Thiazole Derivatives and Use Thereof | APPLIED RESEARCH SYSTEM ARS HOLDING N.V. (NL) | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140228365-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | PF4, TEC, PDGFRB | GAA 4479/4885ALDH1A1 234/4885MAPT 4151/4885 |
| US-20140142103-A1 | Methods and Compositions for Modulating Rad51 and Homologous Recombination | RAD51, MRE11, RAD50 | GAA 4688/4885ALDH1A1 3943/4885MAPT 3907/4885 |
| US-20090029998-A1 | Thiazole Derivatives and Use Thereof | PDGFRB, PDGFRA, TEC | GAA 3788/4885ALDH1A1 174/4885MAPT 1418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.