Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.59 |
| ▸ | APP | P05067 | 3/20 | 0.59 |
| ▸ | CTNNB1 | P35222 | 10/20 | 0.46 |
| ▸ | TCF7L2 | Q9NQB0 | 10/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537447 | 0.86 | ADORA3 (0.45) | ACHEAPPCTNNB1TCF7L2PIK3CA | |
| SCHEMBL3934069 | 0.84 | MKNK2 (0.49) | ACHEAPPPIK3CAMEN1ALDH1A1 | |
| SCHEMBL4566109 | 0.83 | ADORA3 (0.40) | ACHEAPPPIK3CAMEN1ALDH1A1 | |
| SCHEMBL4525792 | 0.82 | ACHE (0.40) | ACHEMEN1ALDH1A1LMNAGAA | |
| SCHEMBL4565682 | 0.82 | TLR8 (0.45) | ACHEAPPCTNNB1TCF7L2MEN1 | |
| SCHEMBL8252450 | 0.81 | ACHE (0.39) | ACHEAPPPIK3CARAB9ASMN1; SMN2 | |
| SCHEMBL4573891 | 0.80 | APP (0.50) | ACHEAPPALDH1A1LMNAMAPT | |
| SCHEMBL4526021 | 0.80 | MAP4K4 (0.45) | PIK3CAMEN1ALDH1A1GAARAB9A | |
| SCHEMBL4534770 | 0.79 | TLR8 (0.39) | ACHEAPPPIK3CARAB9ASMN1; SMN2 | |
| SCHEMBL5121413 | 0.78 | MAP4K4 (0.47) | ACHEAPPCTNNB1TCF7L2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8232278-B2 | Pyrido(3,2-D)pyrimidines and pharmaceutical compositions useful for treating hepatitis C | GILEAD SCIENCES, INC. (US) | 2012-07-31 | — | — | US | disclosed |
| US-20090131414-A1 | PYRIDO(3,2-D)PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR TREATING HEPATITIS C | GILEAD SCIENCES, INC. (US) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131414-A1 | PYRIDO(3,2-D)PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR TREATING HEPATITIS C | DPYD, TYMP, PNPO | ACHE 4292/4885APP 4145/4885CTNNB1 1163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.