Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.65 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | PRCP | P42785 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4520692 | 0.94 | SIGMAR1 (0.71) | SIGMAR1SLC18A3DRD2CARM1PRMT6 | |
| Oxalic Acid SCHEMBL466885 | 0.85 | SIGMAR1 (0.90) | SIGMAR1SLC18A3DRD2HRH3CARM1 | |
| Oxalic Acid SCHEMBL957600 | 0.82 | SIGMAR1 (0.70) | SIGMAR1SLC18A3DRD2HRH3CARM1 | |
| Oxalic Acid SCHEMBL955875 | 0.81 | SIGMAR1 (0.70) | SIGMAR1SLC18A3DRD2HRH3TMEM97 | |
| Oxalic Acid SCHEMBL4108518 | 0.81 | SIGMAR1 (0.55) | SIGMAR1SLC18A3DRD2CARM1PRMT6 | |
| SCHEMBL957621 | 0.79 | SIGMAR1 (1.00) | SIGMAR1SLC18A3DRD2HRH3CARM1 | |
| SCHEMBL17387581 | 0.79 | SLC18A3 (0.45) | SIGMAR1SLC18A3DRD2HRH3CARM1 | |
| SCHEMBL4533962 | 0.77 | SIGMAR1 (0.53) | SIGMAR1SLC18A3DRD2HRH3CARM1 | |
| Oxalic Acid SCHEMBL957708 | 0.76 | SIGMAR1 (0.61) | SIGMAR1SLC18A3PRCPTMEM97 | |
| SCHEMBL955900 | 0.75 | SIGMAR1 (0.77) | SIGMAR1SLC18A3DRD2CARM1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996548-B1 | SIGMA RECEPTOR COMPOUNDS | ESTEVE LABOR DR (ES) | 2016-01-06 | — | — | EP | claimed |
| US-8481567-B2 | Sigma receptor compounds | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2013-07-09 | — | — | US | claimed |
| US-20090197915-A1 | SIGMA RECEPTOR COMPOUNDS | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2009-08-06 | — | — | US | claimed |
| EP-1996548-B1 | SIGMA RECEPTOR COMPOUNDS | ESTEVE LABOR DR (ES) | 2016-01-06 | — | — | EP | disclosed |
| US-8481567-B2 | Sigma receptor compounds | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2013-07-09 | — | — | US | disclosed |
| US-20090197915-A1 | SIGMA RECEPTOR COMPOUNDS | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2009-08-06 | — | — | US | disclosed |
| EP-1829862-A1 | Sigma receptor compounds | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-09-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197915-A1 | SIGMA RECEPTOR COMPOUNDS | SIGMAR1, OPRL1, OPRK1 | SIGMAR1 1/4885SLC18A3 330/4885DRD2 177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.