Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL510134 | 0.86 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3OPRD1MEN1 | |
| Hydrochloric Acid SCHEMBL4386425 | 0.84 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3OPRD1MEN1 | |
| SCHEMBL27666670 | 0.80 | SIGMAR1 (0.41) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11344053 | 0.78 | SLC6A2 (0.35) | SLC6A2SLC6A4SLC6A3OPRD1MEN1 | |
| SCHEMBL29031903 | 0.78 | SIGMAR1 (0.36) | SLC6A2SLC6A4SLC6A3OPRD1 | |
| SCHEMBL23956553 | 0.78 | SLC6A4 (0.39) | SLC6A2SLC6A4SLC6A3OPRD1MEN1 | |
| SCHEMBL26760234 | 0.78 | SLC6A2 (0.33) | SLC6A2SLC6A4SLC6A3OPRD1 | |
| SCHEMBL15658697 | 0.77 | SLC6A4 (0.35) | SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL6956663 | 0.77 | SLC6A2 (0.34) | SLC6A2SLC6A4SLC6A3OPRD1 | |
| SCHEMBL11122182 | 0.75 | SLC6A4 (0.37) | SLC6A2SLC6A4SLC6A3OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4338974-B2 | — | — | 2009-10-07 | — | — | JP | claimed |
| EP-1467721-A2 | SUBSTITUTED AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF ANGIOGENESIS | Amgen Inc. (US) | 2004-10-20 | — | — | EP | claimed |
| JP-2004527499-A | — | — | 2004-09-09 | — | — | JP | claimed |
| WO-2002068406-A2 | SUBSTITUTED AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF ANGIOGENESIS | AMGEN INC. (US) | 2002-09-06 | — | — | WO | claimed |
| EP-1664027-A1 | SUBSTITUTED 2,3-DIHYDRO-1H-ISOINDOL-1-ONE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005021532-A1 | SUBSTITUTED 2,3-DIHYDRO-1H-ISOINDOL-1-ONE DERIVATIVES AND METHODS OF USE | AMGEN INC (US) | 2005-03-10 | — | — | WO | disclosed |