Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 16/20 | 0.46 |
| ▸ | DRD3 | P35462 | 16/20 | 0.46 |
| ▸ | DRD1 | P21728 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | DRD5 | P21918 | 2/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4535003 | 1.00 | DRD2 (0.46) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL4534017 | 0.84 | HRH3 (0.53) | DRD2DRD3DRD1DRD5 | |
| SCHEMBL4534013 | 0.84 | HRH3 (0.53) | DRD2DRD3DRD1DRD5 | |
| SCHEMBL3654090 | 0.84 | DRD2 (0.52) | DRD2DRD3 | |
| SCHEMBL4540321 | 0.77 | HTR1A (0.46) | DRD2DRD3DRD1DRD5 | |
| SCHEMBL4540323 | 0.77 | HTR1A (0.46) | DRD2DRD3DRD1DRD5 | |
| SCHEMBL3653012 | 0.77 | HRH3 (0.47) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL3778639 | 0.77 | HRH3 (0.47) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL23929169 | 0.77 | DRD2 (0.48) | DRD2DRD3 | |
| SCHEMBL3654484 | 0.75 | HRH3 (0.62) | DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069300-A1 | ISOQUINOLINYL AND ISOINDOLINYL DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069300-A1 | ISOQUINOLINYL AND ISOINDOLINYL DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | HRH4, HRH3, HRH2 | DRD2 255/4885DRD3 161/4885DRD1 684/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.