Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.64 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.61 |
| ▸ | FNTA | P49354 | 1/20 | 0.56 |
| ▸ | FNTB | P49356 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 7/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4535362 | 0.81 | KDM4E (0.71) | KDM4EALDH1A1ADORA2ASMN1; SMN2HSD17B10 | |
| SCHEMBL16295335 | 0.79 | KDM4E (0.71) | KDM4EALDH1A1ADORA2ASMN1; SMN2HSD17B10 | |
| SCHEMBL1177057 | 0.79 | KDM4E (1.00) | KDM4EALDH1A1ADORA2ASMN1; SMN2HSD17B10 | |
| SCHEMBL1177499 | 0.79 | KDM4E (0.75) | KDM4EALDH1A1ADORA2ASMN1; SMN2HSD17B10 | |
| SCHEMBL1177695 | 0.77 | KDM4E (0.69) | KDM4EALDH1A1ADORA2ASMN1; SMN2HSD17B10 | |
| SCHEMBL17351540 | 0.76 | KDM4E (0.71) | KDM4EALDH1A1ADORA2ASMN1; SMN2HSD17B10 | |
| SCHEMBL6252358 | 0.76 | KDM4E (1.00) | KDM4EALDH1A1ADORA2ASMN1; SMN2HSD17B10 | |
| SCHEMBL17351373 | 0.75 | KDM4E (0.97) | KDM4EALDH1A1ADORA2ASMN1; SMN2HSD17B10 | |
| SCHEMBL16295295 | 0.72 | RXFP1 (0.69) | KDM4EALDH1A1ADORA2ASMN1; SMN2HSD17B10 | |
| SCHEMBL17351544 | 0.72 | KDM4E (0.64) | KDM4EALDH1A1ADORA2ASMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2556856-A1 | 6-Cyano-substituted Pyrido[2,3-d]pyrimidines as Adenosin Rezeptor Ligands for the Treatment of Cardiovascular Diseases | Bayer Intellectual Property GmbH (DE) | 2013-02-13 | — | — | EP | disclosed |
| EP-2556831-A1 | 3,4-Dihydro-4-oxo-5-aryl-pyrido[2,3-d]pyrimidine-6-carbonitriles as Adenosin Receptor Ligands for Treatment of Cardiovascular Diseases | Bayer Intellectual Property GmbH (DE) | 2013-02-13 | — | — | EP | disclosed |
| EP-2234980-A1 | FUSED CYNOPRYRIDINES AND THE USE THEREOF | Bayer Schering Pharma Aktiengesellschaft (DE) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009080198-A1 | FUSED CYNOPRYRIDINES AND THE USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-07-02 | — | — | WO | disclosed |