Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.58 |
| ▸ | BRD2 | P25440 | 4/20 | 0.58 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.53 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4534759 | 0.89 | RAB9A (0.52) | RAB9APAX8NAMPT | |
| SCHEMBL4539999 | 0.87 | PSEN1 (0.56) | RAB9APAX8NAMPT | |
| SCHEMBL4542841 | 0.87 | RAB9A (0.55) | RAB9APAX8NAMPT | |
| SCHEMBL4542465 | 0.86 | RAB9A (0.48) | BRD4BRD2RAB9APAX8NAMPT | |
| SCHEMBL4537190 | 0.85 | RAB9A (0.60) | RAB9APAX8HCRTR1HCRTR2 | |
| SCHEMBL4537322 | 0.84 | PSEN1 (0.51) | RAB9APAX8HCRTR1HCRTR2 | |
| SCHEMBL4542349 | 0.84 | RAB9A (0.54) | RAB9APAX8 | |
| SCHEMBL4537395 | 0.82 | USP30 (0.50) | BRD4BRD2EPHX2TRPV4RAB9A | |
| SCHEMBL4539344 | 0.80 | BDKRB1 (0.48) | EPHX2RAB9AHCRTR1HCRTR2 | |
| SCHEMBL4541300 | 0.80 | USP30 (0.48) | BRD4BRD2EPHX2TRPV4NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |