Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542465 | 0.97 | RAB9A (0.48) | RAB9ANPC1NAMPTL3MBTL1ALDH1A1 | |
| SCHEMBL4542841 | 0.90 | RAB9A (0.55) | RAB9AMAPTNAMPTALDH1A1TSHR | |
| SCHEMBL4539999 | 0.90 | PSEN1 (0.56) | RAB9AMAPTNAMPTALDH1A1PAX8 | |
| SCHEMBL4535378 | 0.89 | BRD4 (0.58) | RAB9ANAMPTPAX8 | |
| SCHEMBL4537190 | 0.87 | RAB9A (0.60) | RAB9ANPC1PAX8 | |
| SCHEMBL4537322 | 0.87 | PSEN1 (0.51) | RAB9ALMNATSHRPAX8 | |
| SCHEMBL4542349 | 0.86 | RAB9A (0.54) | RAB9AL3MBTL1ALDH1A1PAX8 | |
| SCHEMBL4536845 | 0.85 | RAB9A (0.52) | RAB9ANPC1SMN1; SMN2MAPTTDP1 | |
| SCHEMBL4539344 | 0.82 | BDKRB1 (0.48) | RAB9AALDH1A1 | |
| SCHEMBL4542098 | 0.82 | HTR1A (0.48) | RAB9APAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |