Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 3/20 | 0.76 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.76 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.61 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.61 |
| ▸ | CDC7 | O00311 | 1/20 | 0.61 |
| ▸ | PLK4 | O00444 | 1/20 | 0.61 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.61 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.61 |
| ▸ | CHUK | O15111 | 1/20 | 0.61 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.61 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.61 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.61 |
| ▸ | JAK2 | O60674 | 1/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12072039 | 0.87 | PTK2 (0.73) | MAPK9MAPK10LMNAPTK2FGFR1 | |
| SCHEMBL13450261 | 0.83 | MAPK9 (0.57) | MAPK9MAPK10MEN1KMT2ALMNA | |
| SCHEMBL2423506 | 0.81 | MAPK9 (0.55) | MAPK9MAPK10PTK2FGFR1FGFR3 | |
| SCHEMBL8638460 | 0.81 | L3MBTL1 (0.65) | MEN1KMT2ALMNACHEK1PIM1 | |
| SCHEMBL4304122 | 0.81 | SYK (0.78) | MAPK9MAPK10PTK2FGFR1FGFR3 | |
| SCHEMBL15070048 | 0.80 | PTK2 (0.64) | MAPK9MAPK10LMNAPTK2FGFR1 | |
| SCHEMBL8638027 | 0.79 | MEN1 (0.67) | MAPK9MAPK10MEN1KMT2ALMNA | |
| SCHEMBL6443532 | 0.78 | MEN1 (0.72) | MAPK9MAPK10MEN1KMT2ALMNA | |
| SCHEMBL4022429 | 0.78 | PTK2 (1.00) | MAPK9MAPK10PTK2FGFR1FGFR3 | |
| SCHEMBL28181760 | 0.77 | SIRT2 (0.60) | SIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4377942-B2 | — | — | 2009-12-02 | — | — | JP | claimed |
| JP-2008531599-A | — | — | 2008-08-14 | — | — | JP | claimed |
| EP-1856057-A1 | TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES | Serenex, Inc. (US) | 2007-11-21 | — | — | EP | claimed |
| WO-2006091963-A1 | TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES | SERENEX, INC. (US) | 2006-08-31 | — | — | WO | claimed |