Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.78 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.78 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.78 |
| ▸ | EGFR | P00533 | 18/20 | 0.74 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.71 |
| ▸ | FLT4 | P35916 | 2/20 | 0.71 |
| ▸ | CIT | O14578 | 1/20 | 0.71 |
| ▸ | GAK | O14976 | 1/20 | 0.71 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.71 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.71 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.71 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.71 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.71 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.71 |
| ▸ | STK17B | O94768 | 1/20 | 0.71 |
| ▸ | STK10 | O94804 | 1/20 | 0.71 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.71 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.71 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4565371 | 0.96 | KDR (0.85) | KDREPHB4EPHA2EGFRERBB2 | |
| SCHEMBL7805189 | 0.92 | KDR (0.85) | KDREPHB4EPHA2EGFRERBB2 | |
| SCHEMBL4539126 | 0.90 | EGFR (0.74) | KDREPHB4EPHA2EGFRERBB2 | |
| SCHEMBL907077 | 0.88 | EPHA2 (1.00) | KDREPHB4EPHA2EGFRERBB2 | |
| SCHEMBL9445 | 0.86 | EGFR (0.91) | KDREPHB4EGFRERBB2FLT4 | |
| SCHEMBL28387145 | 0.86 | EPHA2 (0.72) | KDREPHB4EPHA2EGFRERBB2 | |
| SCHEMBL31491085 | 0.86 | EGFR (0.85) | KDREPHB4EGFRERBB2FLT4 | |
| SCHEMBL28520911 | 0.86 | EGFR (0.85) | KDREPHB4EGFRERBB2FLT4 | |
| SCHEMBL5412843 | 0.86 | EGFR (0.84) | KDREPHB4EGFRERBB2FLT4 | |
| SCHEMBL14092460 | 0.86 | EGFR (0.92) | KDREPHB4EGFRERBB2FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892799-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-08-22 | — | — | EP | claimed |
| US-5770603-A | ANTICARCINOGENIC AGENTS | ZENECA LIMITED (GB) | 1998-06-23 | — | — | US | claimed |
| WO-2009070328-A1 | MODULATORS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) PATHWAY FOR USE IN THE TREATMENT OR PREVENTION OF SUBSTANCE ABUSE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-06-04 | — | — | WO | disclosed |
| EP-0892799-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-08-22 | — | — | EP | disclosed |
| EP-0892799-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1999-01-27 | — | — | EP | disclosed |
| US-5770603-A | ANTICARCINOGENIC AGENTS | ZENECA LIMITED (GB) | 1998-06-23 | — | — | US | disclosed |
| WO-1997038994-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-10-23 | — | — | WO | disclosed |