Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17606580 | 0.89 | CHRM2 (0.56) | OPRM1CHRM2CHRM3OPRL1SIGMAR1 | |
| SCHEMBL17606206 | 0.81 | CHRM2 (0.51) | OPRM1CHRM2CHRM3OPRL1SIGMAR1 | |
| SCHEMBL15238945 | 0.81 | OPRM1 (0.50) | OPRM1CHRM2CHRM3OPRL1SIGMAR1 | |
| SCHEMBL19307244 | 0.81 | OPRM1 (0.47) | OPRM1CHRM2CHRM3OPRL1SIGMAR1 | |
| SCHEMBL4940466 | 0.79 | MAPT (0.42) | CHRM4MEN1KMT2A | |
| SCHEMBL18123522 | 0.78 | OPRM1 (0.65) | OPRM1CHRM2CHRM3SIGMAR1CHRM4 | |
| SCHEMBL736647 | 0.77 | HRH3 (0.41) | KMT2AL3MBTL1 | |
| SCHEMBL20274795 | 0.76 | OPRM1 (0.42) | OPRM1CHRM2CHRM3OPRL1POLB | |
| SCHEMBL737369 | 0.76 | HRH3 (0.42) | MEN1KMT2AL3MBTL1 | |
| SCHEMBL17606694 | 0.76 | CYP2D6 (0.53) | OPRM1CHRM2CHRM3OPRL1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2637660-A1 | FATTY ACID SYNTHASE INHIBITORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012064642-A1 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-05-18 | — | — | WO | disclosed |