Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4540776 | 0.92 | MAPT (0.63) | MAPTMAPK1KMT2AMEN1PKM | |
| SCHEMBL8034144 | 0.90 | MAPT (0.66) | MAPTMAPK1KMT2AMEN1PKM | |
| SCHEMBL8041848 | 0.88 | MAPT (0.56) | MAPTMAPK1KMT2AMEN1PKM | |
| SCHEMBL4534800 | 0.86 | KMT2A (0.67) | MAPTMAPK1KMT2AMEN1PKM | |
| SCHEMBL8035392 | 0.86 | PPARG (0.53) | MAPTMAPK1KMT2AMEN1PKM | |
| SCHEMBL4537211 | 0.85 | KCNK3 (0.50) | MAPTKCNK3PTGER4RAB9A | |
| SCHEMBL8040491 | 0.84 | PPARG (0.55) | MAPTMAPK1KMT2AMEN1ATM | |
| SCHEMBL8036315 | 0.84 | MEN1 (0.57) | MAPTMAPK1KMT2AMEN1PKM | |
| SCHEMBL8036312 | 0.84 | PPARG (0.54) | MAPTMAPK1KMT2AMEN1PKM | |
| SCHEMBL8039661 | 0.83 | MAPT (0.50) | MAPTMAPK1KMT2AMEN1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009083526-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-07-09 | — | — | WO | disclosed |
| WO-2009083526-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-07-09 | — | — | WO | disclosed |