Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 17/20 | 0.58 |
| ▸ | EPHX1 | P07099 | 17/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4539882 | 0.95 | EPHX1 (0.56) | EPHX2EPHX1MAPK1 | |
| SCHEMBL8065460 | 0.95 | EPHX1 (0.56) | EPHX2EPHX1MAPK1 | |
| SCHEMBL4535935 | 0.89 | EPHX2 (0.52) | EPHX2EPHX1 | |
| SCHEMBL4537539 | 0.88 | EPHX2 (0.56) | EPHX2EPHX1MAPK1 | |
| SCHEMBL4539563 | 0.88 | EPHX2 (0.56) | EPHX2EPHX1MAPK1 | |
| SCHEMBL4537244 | 0.86 | HSD11B1 (0.52) | EPHX2EPHX1 | |
| SCHEMBL8070996 | 0.86 | HDAC3 (0.52) | EPHX2EPHX1HDAC3HDAC4HDAC1 | |
| SCHEMBL4539753 | 0.86 | HDAC3 (0.49) | EPHX2EPHX1HDAC3HDAC4HDAC1 | |
| SCHEMBL4535493 | 0.86 | HDAC3 (0.52) | EPHX2EPHX1HDAC3HDAC4HDAC1 | |
| SCHEMBL4537010 | 0.86 | EPHX2 (0.55) | EPHX2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |