Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.31 |
| ▸ | RGS12 | O14924 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4262966 | 0.85 | KDM4E (0.37) | KDM4EPRMT5WDR77USP2ALDH1A1 | |
| SCHEMBL22631553 | 0.82 | HTT (0.40) | KDM4EPRMT5WDR77USP2ALDH1A1 | |
| SCHEMBL8534128 | 0.82 | KDM4E (0.43) | KDM4EPRMT5WDR77USP2ALDH1A1 | |
| SCHEMBL3815044 | 0.80 | KDM4E (0.45) | KDM4EPRMT5WDR77USP2ALDH1A1 | |
| SCHEMBL9132499 | 0.80 | KDM4E (0.45) | KDM4EPRMT5WDR77USP2ALDH1A1 | |
| Water SCHEMBL29022494 | 0.79 | KDM4E (0.44) | KDM4EPRMT5WDR77USP2ALDH1A1 | |
| SCHEMBL27303664 | 0.78 | — | — | |
| SCHEMBL6230438 | 0.78 | MEN1 (0.42) | KDM4EPRMT5WDR77USP2ALDH1A1 | |
| SCHEMBL7979196 | 0.77 | KDM4E (0.32) | KDM4EALDH1A1HTTMEN1KMT2A | |
| SCHEMBL20794136 | 0.74 | USP2 (0.50) | KDM4EPRMT5WDR77USP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4377942-B2 | — | — | 2009-12-02 | — | — | JP | claimed |
| JP-2008531599-A | — | — | 2008-08-14 | — | — | JP | claimed |
| CN-101180275-A | Tetrahydroindolone and tetrahydroindazolone derivatives | SERENEX INC (US) | 2008-05-14 | — | — | CN | claimed |
| EP-1856057-A1 | TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES | Serenex, Inc. (US) | 2007-11-21 | — | — | EP | claimed |
| WO-2006091963-A1 | TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES | SERENEX, INC. (US) | 2006-08-31 | — | — | WO | claimed |