Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | G6PD | P11413 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28288419 | 0.89 | MAPT (0.52) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL9584860 | 0.82 | KDM4E (0.46) | MAPTALDH1A1KDM4EL3MBTL1LMNA | |
| SCHEMBL5416008 | 0.80 | SLC6A2 (0.45) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL2350321 | 0.79 | CA12 (0.54) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL2089098 | 0.79 | RXRA (0.49) | ALDH1A1KDM4EL3MBTL1GAASLC6A2 | |
| SCHEMBL10316560 | 0.79 | L3MBTL1 (0.53) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL2770865 | 0.79 | MAPT (0.44) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL535975 | 0.79 | RXRA (0.49) | L3MBTL1MRGPRX1 | |
| SCHEMBL14237715 | 0.78 | MAPT (0.42) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL3035171 | 0.77 | MAPT (0.45) | MAPTALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012147019-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF SILODOSIN | ORCHID CHEMICALS AND PHARAMCEUTICALS LIMITED (IN) | 2012-11-01 | — | — | WO | disclosed |
| WO-2012062229-A1 | A METHOD OF MANUFACTURING (-)-L-(3-HYDROXYPROPYL)-5-[(2R)-2-({2,2,2-TRIFLUOROETHOXY)- PHENOXYETHYL}AMINO)PROPYL]-2,3-DIHYDRO-LH-INDOLE-7-CARBOXAMIDE | ZENTIVA, K.S. (CZ) | 2012-05-18 | — | — | WO | disclosed |
| EP-0600675-B1 | Indoline compounds for the treatment of dysuria | KISSEI PHARMACEUTICAL (JP) | 1998-07-08 | — | — | EP | disclosed |
| US-5387603-A | Treating dysuria (painful urination) with less hypotension; FDA Orange book listed patent for silodosin | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1995-02-07 | — | — | US | disclosed |
| EP-0600675-A1 | Indoline compounds for the treatment of dysuria | Kissei Pharmaceutical Co., Ltd. (JP) | 1994-06-08 | — | — | EP | disclosed |