Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 9/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4533493 | 0.97 | ALDH1A1 (0.48) | ALDH1A1LMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL8064930 | 0.87 | EPHX2 (0.43) | ALDH1A1EPHX2P2RX7HRH3CYP2C9 | |
| SCHEMBL4537463 | 0.87 | EPHX2 (0.49) | ALDH1A1EPHX2P2RX7HRH3CYP2C9 | |
| SCHEMBL4538180 | 0.86 | KMT2A (0.44) | ALDH1A1LMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL4534910 | 0.85 | EPHX2 (0.46) | ALDH1A1LMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL8061617 | 0.85 | EPHX2 (0.41) | ALDH1A1EPHX2P2RX7HRH3CYP2C9 | |
| SCHEMBL4542900 | 0.84 | EPHX2 (0.47) | ALDH1A1EPHX2P2RX7HRH3CYP2C9 | |
| SCHEMBL4531267 | 0.84 | EPHX2 (0.66) | ALDH1A1LMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL4541185 | 0.84 | HTT (0.48) | ALDH1A1LMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL4535381 | 0.83 | EPHX2 (0.58) | EPHX2EPHX1CYP2C9CYP2J2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |