SCHEMBL4537591

SCHEMBL4537591

O=C(COc1ccc(Cl)c2c(=O)c3ccccc3sc12)N(CCO)CCO

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.38
MAPT P10636 4/20 0.37
LMNA P02545 3/20 0.37
RAB9A P51151 3/20 0.37
CYP1A2 P05177 2/20 0.37
CYP3A4 P08684 2/20 0.37
RAD52 P43351 2/20 0.37
CHRM2 P08172 2/20 0.37
HTR1A P08908 2/20 0.37
ADRA2A P08913 2/20 0.37
CHRM1 P11229 2/20 0.37
TBXA2R P21731 2/20 0.37
SLC6A2 P23975 2/20 0.37
APEX1 P27695 2/20 0.37
SLC6A4 P31645 2/20 0.37
ADRA1A P35348 2/20 0.37
OPRM1 P35372 2/20 0.37
DRD3 P35462 2/20 0.37
SLC6A3 Q01959 2/20 0.37
KMT2A Q03164 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25828115 0.86 POLB (0.37) POLBMAPTLMNARAB9ACYP1A2
SCHEMBL4562611 0.86 TOP2A (0.31) POLBMAPTLMNARAB9ACYP1A2
SCHEMBL16434697 0.84 MAPT (0.40) POLBMAPTLMNARAB9ACYP1A2
SCHEMBL2126462 0.84 PTPN1 (0.49) POLBMAPTRAB9ACYP1A2CYP3A4
SCHEMBL30080217 0.84 PTPN1 (0.49) POLBMAPTRAB9ACYP1A2CYP3A4
SCHEMBL19389781 0.83 MAPT (0.41) POLBMAPTLMNARAB9ACYP1A2
SCHEMBL13066138 0.83 MAPT (0.40) POLBMAPTLMNARAB9ACYP1A2
SCHEMBL30549323 0.83 MAOA (0.42) POLBMAPTLMNARAB9ACYP1A2
SCHEMBL4539472 0.83 MAOA (0.42) POLBMAPTLMNARAB9ACYP1A2
SCHEMBL13859939 0.82 F9 (0.46) MAPTLMNARAB9ACYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3369751-A1 NOVEL PHOTOINITIATORS Coloplast A/S (DK) 2018-09-05 EP claimed
US-9371308-B2 Polymeric photoinitiators COLOPLAST A/S (DK) 2016-06-21 US claimed
EP-2638078-B1 NEW ROUTES TO POLYACRYLATES COLOPLAST AS (DK) 2015-01-07 EP claimed
EP-2638077-B1 NOVEL POLYMERIC PHOTOINITIATORS COLOPLAST AS (DK) 2015-01-07 EP claimed
US-20130296577-A1 NOVEL PHOTOINITIATORS COLOPLAST A/S (DK) 2013-11-07 US claimed
US-20130296454-A1 ROUTES TO POLYACRYLATES COLOPLAST A/S (DK) 2013-11-07 US claimed
US-20130289155-A1 NOVEL POLYMERIC PHOTOINITIATORS COLOPLAST A/S (DK) 2013-10-31 US claimed
EP-2638076-A2 NOVEL PHOTOINITIATORS Coloplast A/S (DK) 2013-09-18 EP claimed
WO-2012062332-A2 NOVEL PHOTOINITIATORS COLOPLAST A/S (DK) 2012-05-18 WO claimed
EP-3369751-A1 NOVEL PHOTOINITIATORS Coloplast A/S (DK) 2018-09-05 EP disclosed
US-9708425-B2 Routes to polyacrylates COLOPLAST A/S (DK) 2017-07-18 US disclosed
US-9670373-B2 Polymers comprising photoinitiator moieties and dye moieties LAMBSON LIMITED (GB) 2017-06-06 US disclosed
US-9399633-B2 Photoinitiators COLOPLAST A/S (DK) 2016-07-26 US disclosed
US-9371308-B2 Polymeric photoinitiators COLOPLAST A/S (DK) 2016-06-21 US disclosed
US-20130289155-A1 NOVEL POLYMERIC PHOTOINITIATORS COLOPLAST A/S (DK) 2013-10-31 US disclosed
EP-2638078-A1 NEW ROUTES TO POLYACRYLATES Coloplast A/S (DK) 2013-09-18 EP disclosed
EP-2638077-A1 NOVEL POLYMERIC PHOTOINITIATORS Coloplast A/S (DK) 2013-09-18 EP disclosed
WO-2013026451-A1 POLYMERS COMPRISING PHOTOINITIATOR MOIETIES AND DYE MOIETIES COLOPLAST A/S (DK) 2013-02-28 WO disclosed
WO-2012062334-A1 NEW ROUTES TO POLYACRYLATES COLOPLAST A/S (DK) 2012-05-18 WO disclosed
WO-2012062333-A1 NOVEL POLYMERIC PHOTOINITIATORS COLOPLAST A/S (DK) 2012-05-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130296577-A1 NOVEL PHOTOINITIATORS UROD, PUF60, PARG POLB 455/4885MAPT 24/4885LMNA 2705/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.