Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | THRA | P10827 | 7/20 | 0.47 |
| ▸ | THRB | P10828 | 7/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4361817 | 0.86 | THRA (0.52) | MEN1KMT2ASMN1; SMN2HPGDLMNA | |
| SCHEMBL4354874 | 0.83 | THRA (0.53) | MEN1KMT2ASMN1; SMN2HPGDLMNA | |
| SCHEMBL4349690 | 0.83 | THRA (0.64) | MEN1KMT2ASMN1; SMN2HPGDLMNA | |
| SCHEMBL4540037 | 0.82 | THRA (0.69) | MEN1KMT2ASMN1; SMN2HPGDLMNA | |
| SCHEMBL4349556 | 0.82 | THRA (0.52) | MEN1KMT2ASMN1; SMN2HPGDLMNA | |
| SCHEMBL4356831 | 0.80 | THRA (0.58) | MEN1KMT2ASMN1; SMN2HPGDLMNA | |
| SCHEMBL4351576 | 0.80 | THRA (0.53) | MEN1KMT2ASMN1; SMN2THRATHRB | |
| SCHEMBL4354704 | 0.80 | THRA (0.50) | MEN1KMT2ASMN1; SMN2HPGDLMNA | |
| SCHEMBL4348053 | 0.79 | THRA (0.52) | MEN1KMT2ASMN1; SMN2HPGDLMNA | |
| SCHEMBL4350209 | 0.79 | SENP5 (0.52) | MEN1KMT2ASMN1; SMN2HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080835-A1 | THYROMIMETRIC COMPOUNDS IN TREATMENT OF DISEASE RELATED TO SONIC HEDGEHOG SIGNALLING | KARO BIO AB (SE) | 2009-07-02 | — | — | WO | claimed |