Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4539918 | 0.85 | MAPT (0.49) | KMT2AMEN1MAPTGAASMN1; SMN2 | |
| SCHEMBL4543706 | 0.82 | KDM4C (0.38) | KMT2AMEN1L3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL4541242 | 0.82 | SMN1; SMN2 (0.59) | RAB9AKMT2AMEN1MAPTGAA | |
| SCHEMBL5320659 | 0.80 | KDM4E (0.38) | KMT2AMEN1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4539912 | 0.79 | KMT2A (0.50) | NPC1RAB9AKMT2AL3MBTL1MAPT | |
| SCHEMBL4543579 | 0.79 | SMN1; SMN2 (0.55) | RAB9AKMT2AMEN1MAPTGAA | |
| SCHEMBL4540559 | 0.78 | MEN1 (0.51) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL4540543 | 0.77 | MAPT (0.66) | NPC1RAB9AKMT2AMEN1L3MBTL1 | |
| SCHEMBL9311412 | 0.76 | KMT2A (0.48) | NPC1RAB9AKMT2AMEN1L3MBTL1 | |
| SCHEMBL4541462 | 0.76 | SMN1; SMN2 (0.47) | NPC1RAB9AKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |