SCHEMBL4543706

SCHEMBL4543706

O=C(O)c1ccnn1-c1ncc(Cl)cc1Cl

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KDM4C Q9H3R0 5/20 0.38
KDM5A P29375 5/20 0.37
KDM5B Q9UGL1 5/20 0.37
LMNA P02545 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
P2RX7 Q99572 1/20 0.35
CCR9 P51686 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
MAPT P10636 2/20 0.35
MEN1 O00255 1/20 0.35
ALDH1A1 P00352 1/20 0.35
HPGD P15428 1/20 0.35
KMT2A Q03164 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
TSHR P16473 1/20 0.34
CASP1 P29466 1/20 0.34
HTT P42858 1/20 0.34
HCAR2 Q8TDS4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15741922 0.87 MALT1 (0.37) LMNAL3MBTL1P2RX7SMN1; SMN2MAPT
SCHEMBL29785385 0.87 MALT1 (0.37) LMNAL3MBTL1P2RX7SMN1; SMN2MAPT
SCHEMBL5320659 0.86 KDM4E (0.38) KDM4CKDM5AKDM5BSMN1; SMN2MAPT
SCHEMBL4538115 0.82 NPC1 (0.48) LMNAL3MBTL1SMN1; SMN2MAPTMEN1
SCHEMBL950180 0.79 MALT1 (0.41) KDM4CLMNAL3MBTL1SMN1; SMN2MEN1
SCHEMBL10468509 0.76 LMNA (0.52) KDM4CLMNASMN1; SMN2MAPTMEN1
SCHEMBL1198603 0.75 L3MBTL1 (0.35) LMNAL3MBTL1P2RX7CCR9MAPT
SCHEMBL1199256 0.75 KMT2A (0.42) LMNAL3MBTL1P2RX7SMN1; SMN2MAPT
SCHEMBL29920957 0.75 L3MBTL1 (0.35) LMNAL3MBTL1P2RX7CCR9MAPT
SCHEMBL10684842 0.75 POLB (0.41) LMNAP2RX7SMN1; SMN2MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-217910383-U Reaction device of o-formamido benzamide compound 山东友道化学有限公司 2022-11-29 CN disclosed
WO-2009117421-A2 HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE KALYPSYS, INC. (US) 2009-09-24 WO disclosed
WO-2009117421-A2 HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE KALYPSYS, INC. (US) 2009-09-24 WO disclosed