Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 17/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 16/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537966 | 0.94 | LMNA (0.57) | EPHX1EPHX2LMNAGFER | |
| SCHEMBL4539891 | 0.89 | LMNA (0.65) | EPHX1EPHX2LMNA | |
| SCHEMBL8064838 | 0.89 | EPHX1 (0.68) | EPHX1EPHX2 | |
| SCHEMBL4542200 | 0.89 | LMNA (0.54) | EPHX1EPHX2LMNAGFER | |
| SCHEMBL4537354 | 0.88 | EPHX1 (0.63) | EPHX1EPHX2 | |
| SCHEMBL4542983 | 0.85 | EPHX1 (0.57) | EPHX1EPHX2LMNAGFER | |
| SCHEMBL8059951 | 0.83 | EPHX2 (0.60) | EPHX1EPHX2 | |
| SCHEMBL4535921 | 0.83 | EPHX1 (0.53) | EPHX1EPHX2 | |
| SCHEMBL4533513 | 0.83 | EPHX2 (0.60) | EPHX1EPHX2 | |
| SCHEMBL4539041 | 0.83 | LMNA (0.60) | EPHX1EPHX2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |