Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 14/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 13/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537966 | 0.95 | LMNA (0.57) | LMNAEPHX1EPHX2GFER | |
| SCHEMBL8060906 | 0.91 | LMNA (0.52) | LMNAEPHX1EPHX2GFER | |
| SCHEMBL4540005 | 0.90 | LMNA (0.57) | LMNAEPHX1EPHX2 | |
| SCHEMBL8060768 | 0.90 | LMNA (0.57) | LMNAEPHX1EPHX2 | |
| SCHEMBL4542921 | 0.90 | CYP3A4 (0.57) | EPHX1EPHX2 | |
| SCHEMBL8062904 | 0.90 | EPHX2 (0.59) | EPHX1EPHX2 | |
| SCHEMBL4537586 | 0.90 | EPHX1 (0.52) | LMNAEPHX1EPHX2 | |
| SCHEMBL4538172 | 0.89 | EPHX1 (0.58) | LMNAEPHX1EPHX2GFER | |
| SCHEMBL4542593 | 0.89 | EPHX1 (0.50) | LMNAEPHX1EPHX2 | |
| SCHEMBL4541299 | 0.88 | EPHX1 (0.51) | LMNAEPHX1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |