Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8768499 | 0.79 | ALDH1A1 (0.63) | TDP1POLBALDH1A1TP53NPSR1 | |
| SCHEMBL11828437 | 0.77 | STAT3 (0.47) | TDP1ALDH1A1TP53LMNASMN1; SMN2 | |
| SCHEMBL6924285 | 0.76 | LMNA (0.59) | LMNASMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL9311743 | 0.75 | RECQL (0.57) | TDP1ALDH1A1TP53LMNASMN1; SMN2 | |
| SCHEMBL12661780 | 0.75 | ALDH1A1 (0.55) | ALDH1A1TP53NPSR1LMNASMN1; SMN2 | |
| SCHEMBL31606584 | 0.73 | CA12 (0.49) | TDP1ALDH1A1LMNASMN1; SMN2CYP2C9 | |
| SCHEMBL8746169 | 0.73 | NPSR1 (0.44) | ALDH1A1NPSR1HPGDSTAT3 | |
| SCHEMBL10539569 | 0.72 | STAT3 (0.48) | TDP1ALDH1A1NPSR1LMNACYP2C9 | |
| SCHEMBL13528494 | 0.72 | MAPT (0.47) | POLBALDH1A1SMN1; SMN2HPGDMEN1 | |
| SCHEMBL9550978 | 0.72 | ALDH1A1 (0.50) | ALDH1A1LMNASMN1; SMN2CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160215006-A1 | PEPTIDOMIMETIC INHIBITORS OF PSMA | WASHINGTON STATE UNIVERSITY (US) | 2016-07-28 | — | — | US | disclosed |
| US-9328129-B2 | Peptidomimetic inhibitors of PSMA | WASHINGTON STATE UNIVERSITY (US) | 2016-05-03 | — | — | US | disclosed |
| US-20140010758-A1 | PEPTIDOMIMETIC INHIBITORS OF PSMA | THE REGEANTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-01-09 | — | — | US | disclosed |
| WO-2012064914-A2 | PEPTIDOMIMETIC INHIBITORS OF PSMA | WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160215006-A1 | PEPTIDOMIMETIC INHIBITORS OF PSMA | PSMA1, PSMA3, PSMA2 | TDP1 3315/4885POLB 2756/4885ALDH1A1 3493/4885 |
| US-20140010758-A1 | PEPTIDOMIMETIC INHIBITORS OF PSMA | PSMA1, PSMA3, PSMA2 | TDP1 3315/4885POLB 2756/4885ALDH1A1 3493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.