Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 4/20 | 0.44 |
| ▸ | HRH1 | P35367 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27539875 | 0.83 | KDM4E (0.43) | KDM4EALDH1A1HTR2AHRH1TDP1 | |
| SCHEMBL8506364 | 0.79 | LMNA (0.39) | KDM4EHTR2AHRH1LMNACYP1A2 | |
| SCHEMBL4975762 | 0.76 | KDM4E (0.38) | KDM4EALDH1A1HTR2AHRH1TDP1 | |
| SCHEMBL674996 | 0.76 | CHRNA7 (0.59) | KDM4EALDH1A1HTR2AHRH1TDP1 | |
| Bromide SCHEMBL10595079 | 0.74 | CHRNA7 (0.56) | KDM4EALDH1A1HTR2AHRH1TDP1 | |
| Water SCHEMBL28355612 | 0.74 | CHRNA7 (0.56) | KDM4EALDH1A1HTR2AHRH1TDP1 | |
| Hydrochloric Acid SCHEMBL11332719 | 0.74 | CHRNA7 (0.56) | KDM4EALDH1A1HTR2AHRH1TDP1 | |
| SCHEMBL9329234 | 0.73 | HTR2A (0.43) | KDM4EALDH1A1HTR2AHRH1TDP1 | |
| SCHEMBL11866446 | 0.72 | LMNA (0.46) | KDM4EHTR2AHRH1TDP1LMNA | |
| SCHEMBL6131994 | 0.72 | MEN1 (0.41) | KDM4EALDH1A1HTR2AHRH1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130296279-A1 | SUBSTITUTED TETRACYCLINES | CONCERT PHARMACEUTICALS INC. | 2013-11-07 | — | — | US | disclosed |
| WO-2012065028-A2 | SUBSTITUTED TETRACYCLINES | CONCERT PHARMACEUTICALS INC. (US) | 2012-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130296279-A1 | SUBSTITUTED TETRACYCLINES | TET1, TET3, SLC10A2 | KDM4E 788/4885ALDH1A1 1432/4885HTR2A 2284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.