Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.70 |
| ▸ | KRAS | P01116 | 3/20 | 0.70 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.70 |
| ▸ | GALR3 | O60755 | 1/20 | 0.69 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.69 |
| ▸ | TNF | P01375 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4538841 | 1.00 | EGFR (0.70) | EGFRKRASSOS1GALR3NR2F2 | |
| Hydrochloric Acid SCHEMBL7222514 | 0.99 | EGFR (0.68) | EGFRKRASSOS1GALR3NR2F2 | |
| Hydrochloric Acid SCHEMBL7222518 | 0.99 | EGFR (0.68) | EGFRKRASSOS1GALR3NR2F2 | |
| Hydrochloric Acid SCHEMBL7222481 | 0.97 | EGFR (0.67) | EGFRKRASSOS1GALR3NR2F2 | |
| Hydrochloric Acid SCHEMBL7222486 | 0.97 | EGFR (0.67) | EGFRKRASSOS1GALR3NR2F2 | |
| SCHEMBL17181108 | 0.82 | GALR3 (1.00) | EGFRKRASSOS1GALR3NR2F2 | |
| SCHEMBL5312802 | 0.82 | GALR3 (1.00) | EGFRKRASSOS1GALR3NR2F2 | |
| SCHEMBL31505705 | 0.82 | GALR3 (0.72) | EGFRKRASSOS1GALR3NR2F2 | |
| SCHEMBL13283262 | 0.82 | GALR3 (0.72) | EGFRKRASSOS1GALR3NR2F2 | |
| SCHEMBL31505701 | 0.82 | GALR3 (0.72) | EGFRKRASSOS1GALR3NR2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596726-B1 | Method of inhibiting epidermal growth factor by treating, with an effective inhibiting amount, a mammal, in need thereof inhibit the epidermal growth factor receptor and related receptors and, in particular, their tyrosine kinase enzyme | WARNER LAMBERT COMPANY | 2003-07-22 | — | — | US | claimed |
| WO-2009070328-A1 | MODULATORS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) PATHWAY FOR USE IN THE TREATMENT OR PREVENTION OF SUBSTANCE ABUSE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-06-04 | — | — | WO | disclosed |