Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.73 |
| ▸ | DRD4 | P21917 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | CCR2 | P41597 | 2/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | LSS | P48449 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22516947 | 0.87 | DRD2 (0.56) | DRD2DRD4LMNALSSHSP90AA1 | |
| SCHEMBL6442002 | 0.85 | DRD4 (0.66) | DRD2DRD4HTR2AHTR2CHTR2B | |
| SCHEMBL8781020 | 0.82 | DRD4 (0.60) | DRD2DRD4HTR2AHTR2CHTR2B | |
| SCHEMBL6031812 | 0.81 | DRD4 (1.00) | DRD2DRD4SIGMAR1 | |
| SCHEMBL12668155 | 0.80 | GAA (0.59) | DRD2 | |
| SCHEMBL5542706 | 0.80 | DRD4 (0.77) | DRD2DRD4HTR2AHTR2CHTR2B | |
| SCHEMBL12385909 | 0.80 | DRD4 (0.77) | DRD2DRD4LMNAHTR2AHTR2C | |
| SCHEMBL10438222 | 0.78 | DRD4 (0.64) | DRD2DRD4HTR2AHTR2CHTR2B | |
| SCHEMBL588149 | 0.78 | DRD4 (1.00) | DRD2DRD4LMNAHTR2CL3MBTL1 | |
| SCHEMBL6794331 | 0.78 | DRD4 (0.79) | DRD2DRD4HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064569-A1 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-05-18 | — | — | WO | disclosed |