Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 3/20 | 0.66 |
| ▸ | CA1 | P00915 | 13/20 | 0.64 |
| ▸ | CA2 | P00918 | 13/20 | 0.64 |
| ▸ | CA9 | Q16790 | 10/20 | 0.64 |
| ▸ | CA7 | P43166 | 9/20 | 0.64 |
| ▸ | CA12 | O43570 | 5/20 | 0.64 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.58 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4539301 | 0.85 | DRD2 (0.73) | DRD4DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL10438222 | 0.84 | DRD4 (0.64) | DRD4CA1CA2CA9CA12 | |
| SCHEMBL6031812 | 0.81 | DRD4 (1.00) | DRD4ALDH1A1DRD2 | |
| SCHEMBL26668277 | 0.80 | CA1 (0.50) | CA1CA2CA9CA7CA12 | |
| SCHEMBL5542706 | 0.80 | DRD4 (0.77) | DRD4DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL654308 | 0.80 | DRD4 (0.77) | DRD4DRD2HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL9742129 | 0.78 | DRD4 (0.74) | DRD4DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL588149 | 0.78 | DRD4 (1.00) | DRD4ALDH1A1DRD2HTR2C | |
| SCHEMBL6794331 | 0.78 | DRD4 (0.79) | DRD4ALDH1A1DRD2HTR2AHTR2C | |
| SCHEMBL19014647 | 0.78 | BCL2 (0.64) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1226128-B1 | NEW PYRIMIDINE-2,4,6-TRIONE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2005-02-23 | — | — | EP | disclosed |
| CN-1157382-C | Novel pyrimidine-2, 4, 6-trione derivatives, process for their production and pharmaceutical agents containing these compounds | - | 2004-07-14 | — | — | CN | disclosed |
| US-6498252-B1 | Pyrimidine-2,4,6-trione derivatives, processes for their production and pharmaceutical agents containing these compounds | HOFFMANN-LA ROCHE INC. | 2002-12-24 | — | — | US | disclosed |
| CN-1374954-A | Novel pyrimidine-2, 4, 6-trione derivatives, process for their production and pharmaceutical agents containing these compounds | HOFFMANN LA ROCHE (CH) | 2002-10-16 | — | — | CN | disclosed |
| EP-1226128-A1 | NEW PYRIMIDINE-2,4,6-TRIONE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-31 | — | — | EP | disclosed |
| WO-2001025217-A1 | NEW PYRIMIDINE-2,4,6-TRIONE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-12 | — | — | WO | disclosed |