SCHEMBL453966

SCHEMBL453966

Nc1nc(=O)n([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1C=O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.59
MTOR P42345 2/20 0.59
ALDH1A1 P00352 2/20 0.59
TP53 P04637 2/20 0.59
THRB P10828 1/20 0.59
MDM2 Q00987 1/20 0.59
NCOA1 Q15788 1/20 0.59
NCOA3 Q9Y6Q9 1/20 0.59
GMNN O75496 1/20 0.59
NFKB1 P19838 1/20 0.59
DNMT1 P26358 1/20 0.59
THPO P40225 1/20 0.59
HTT P42858 1/20 0.59
RAB9A P51151 1/20 0.59
BLM P54132 1/20 0.59
HBB P68871 1/20 0.59
PMP22 Q01453 1/20 0.59
SMN1; SMN2 Q16637 2/20 0.53
POLB P06746 1/20 0.53
MAPT P10636 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL453967 1.00 LMNA (0.59) LMNAMTORALDH1A1TP53THRB
SCHEMBL14853910 1.00 LMNA (0.59) LMNAMTORALDH1A1TP53THRB
SCHEMBL16974936 0.92 LMNA (0.51) LMNAMTORALDH1A1TP53THRB
SCHEMBL18513007 0.90 LMNA (0.47) LMNAMTORALDH1A1TP53THRB
SCHEMBL11317700 0.89 LMNA (0.58) LMNAMTORALDH1A1TP53THRB
SCHEMBL2584925 0.89 LMNA (0.58) LMNAMTORALDH1A1TP53THRB
SCHEMBL11317699 0.89 LMNA (0.58) LMNAMTORALDH1A1TP53THRB
SCHEMBL16805382 0.89 LMNA (0.58) LMNAMTORALDH1A1TP53THRB
SCHEMBL11331733 0.89 LMNA (0.58) LMNAMTORALDH1A1TP53THRB
SCHEMBL16809039 0.89 LMNA (0.58) LMNAMTORALDH1A1TP53THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 5270 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12636304-B2 2026-05-26 US claimed
US-20260139030-A1 CHIMERIC PROTEINS FOR TREATING CUTANEOUS INFLAMMATION SHATTUCK LABS INC (US) 2026-05-21 US claimed
US-12618064-B2 Acetylated ribonucleic acids and uses thereof HELIX NANOTECHNOLOGIES INC (US) 2026-05-05 US claimed
WO-2026089664-A1 GENERALISED FRAMEWORK FOR IDENTIFICATION OF RNA MODIFICATION ON SPECIFIC SEQUENCES AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2026-04-30 WO claimed
US-20260108554-A1 METHODS FOR REPROGRAMMING AND GENE EDITING CELLS FACTOR BIOSCIENCE INC (US) 2026-04-23 US claimed
US-12606866-B2 Methods for the amplification of bisulfite-treated DNA THE UNIVERSITY OF CHICAGO (US) 2026-04-21 US claimed
US-20260103701-A1 TET-ASSISTED PYRIDINE BORANE SEQUENCING EXACT SCIENCES INNOVATION LTD (GB) 2026-04-16 US claimed
US-12601006-B2 Targeted, long-read nucleic acid sequencing for the determination of cytosine modifications LUDWIG INSTITUTE FOR CANCER RESEARCH LTD. (CH) 2026-04-14 US claimed
EP-4720279-A2 CIS-REGULATORY ELEMENTS OF TRANSLATION AND METHODS USING SAME Yale University (US) 2026-04-08 EP claimed
EP-4716748-A2 METHOD OF MODULATING MRNA TRANSLATION Yale University (US) 2026-04-01 EP claimed
WO-2013151672-A2 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF ONCOLOGY-RELATED PROTEINS AND PEPTIDES modeRNA Therapeutics (US) 2013-10-10 WO claimed
WO-2013151671-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF COSMETIC PROTEINS AND PEPTIDES modeRNA Therapeutics (US) 2013-10-10 WO claimed
WO-2013151736-A2 IN VIVO PRODUCTION OF PROTEINS modeRNA Therapeutics (US) 2013-10-10 WO claimed
EP-2578685-A2 RNA containing modified nucleosides and methods of use thereof The Trustees of The University of Pennsylvania (US) 2013-04-10 EP claimed
WO-2013039861-A2 ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF modeRNA Therapeutics (US) 2013-03-21 WO claimed
WO-2012158736-A1 ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF FOR NON-HUMAN VERTEBRATES modeRNA Therapeutics (US) 2012-11-22 WO claimed
US-20120251618-A1 DELIVERY AND FORMULATION OF ENGINEERED NUCLEIC ACIDS modeRNA Therapeutics (US) 2012-10-04 US claimed
WO-2012135805-A2 DELIVERY AND FORMULATION OF ENGINEERED NUCLEIC ACIDS modeRNA Therapeutics (US) 2012-10-04 WO claimed
EP-2201118-B1 COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF RETROVIRAL INFECTION TRANA DISCOVERY (US) 2012-04-18 EP claimed
CN-101855351-A Compositions and methods for the identification of inhibitors of retroviral infection TRANA DISCOVERY 2010-10-06 CN claimed