Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | KIF11 | P52732 | 1/20 | 0.54 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4167158 | 1.00 | CYP2C9 (0.62) | CYP2C9KIF11PTPN5PTPN1MAPT | |
| SCHEMBL1063470 | 1.00 | CYP2C9 (0.62) | CYP2C9KIF11PTPN5PTPN1MAPT | |
| SCHEMBL4517127 | 0.87 | MAPT (0.50) | CYP2C9PTPN1MAPTKMT2A | |
| SCHEMBL4517619 | 0.87 | MAPT (0.50) | CYP2C9PTPN1MAPTKMT2A | |
| SCHEMBL4517129 | 0.87 | MAPT (0.50) | CYP2C9PTPN1MAPTKMT2A | |
| Water SCHEMBL4920744 | 0.82 | CYP2C9 (0.50) | CYP2C9KIF11PTPN5PTPN1MAPT | |
| SCHEMBL31619475 | 0.81 | CES2 (0.52) | KIF11PTPN1NPC1RAB9AAPP | |
| SCHEMBL27608748 | 0.79 | PDK1 (0.51) | CYP2C9SMN1; SMN2KMT2ANPC1RAB9A | |
| SCHEMBL1679690 | 0.79 | CYP2C9 (0.61) | CYP2C9KIF11PTPN5MAPTSMN1; SMN2 | |
| SCHEMBL3087883 | 0.79 | CYP2C9 (0.61) | CYP2C9KIF11PTPN5MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2468270-A1 | (R)-2-(3-fluoro-4-phenylphenyl)propionic acid for use in the treatment of skin diseases | GALENpharma GmbH (DE) | 2012-06-27 | — | — | EP | disclosed |
| WO-2009034457-A1 | ORGANIC COMPOUNDS USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES, USES AND METHODS FOR THE PREPARATION THEREOF | ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA (IT) | 2009-03-19 | — | — | WO | disclosed |