Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 10/20 | 0.36 |
| ▸ | THRA | P10827 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.32 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4295275 | 0.82 | ATM (0.38) | EGLN1THRATHRBATM | |
| SCHEMBL3980253 | 0.79 | EGLN1 (0.40) | EGLN1THRATHRBATMHIF1A | |
| SCHEMBL4299059 | 0.75 | KDM4E (0.37) | EGLN1THRATHRBGAA | |
| SCHEMBL3978301 | 0.75 | THRB (0.37) | THRATHRB | |
| SCHEMBL3986363 | 0.70 | THRB (0.37) | THRATHRB | |
| SCHEMBL13625961 | 0.62 | EGLN1 (0.82) | EGLN1 | |
| SCHEMBL4305878 | 0.60 | EGLN1 (0.81) | EGLN1 | |
| SCHEMBL10871977 | 0.60 | SMN1; SMN2 (0.52) | — | |
| SCHEMBL3976827 | 0.60 | THRB (0.39) | EGLN1THRATHRB | |
| SCHEMBL3979453 | 0.59 | THRB (0.34) | THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080835-A1 | THYROMIMETRIC COMPOUNDS IN TREATMENT OF DISEASE RELATED TO SONIC HEDGEHOG SIGNALLING | KARO BIO AB (SE) | 2009-07-02 | — | — | WO | disclosed |