Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 7/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 4/20 | 0.37 |
| ▸ | F9 | P00740 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3982070 | 0.83 | THRA (0.49) | THRBTHRAKDM4E | |
| SCHEMBL3978770 | 0.79 | THRA (0.36) | THRBTHRAKDM4E | |
| SCHEMBL4295275 | 0.77 | ATM (0.38) | THRBEGLN1THRA | |
| SCHEMBL3981285 | 0.77 | EGLN1 (0.38) | THRBEGLN1THRA | |
| SCHEMBL3141209 | 0.71 | THRB (0.46) | THRBEGLN1THRA | |
| SCHEMBL4299059 | 0.71 | KDM4E (0.37) | THRBEGLN1THRAMAPTKDM4E | |
| SCHEMBL3989613 | 0.70 | THRB (0.41) | THRBTHRAMAPTKDM4E | |
| SCHEMBL3138206 | 0.70 | THRB (0.42) | THRBEGLN1THRA | |
| SCHEMBL4299815 | 0.70 | THRB (0.45) | THRBEGLN1THRAMAPTKDM4E | |
| SCHEMBL3137311 | 0.69 | THRB (0.42) | THRBEGLN1THRAKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080835-A1 | THYROMIMETRIC COMPOUNDS IN TREATMENT OF DISEASE RELATED TO SONIC HEDGEHOG SIGNALLING | KARO BIO AB (SE) | 2009-07-02 | — | — | WO | disclosed |
| EP-2024336-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS | KARO BIO AB (SE) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007128492-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS | KARO BIO AB (SE) | 2007-11-15 | — | — | WO | disclosed |