Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | CCR1 | P32246 | 3/20 | 0.44 |
| ▸ | CCR5 | P51681 | 3/20 | 0.44 |
| ▸ | CCR8 | P51685 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | METAP1 | P53582 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688201 | 0.81 | CCR1 (0.46) | KDM4ENPC1CCR1CCR5CCR8 | |
| SCHEMBL17943880 | 0.77 | KDM4E (0.42) | KDM4ENPC1LMNAMETAP1MAPT | |
| SCHEMBL25551963 | 0.77 | HTT (0.37) | KDM4ENPC1CYP1A2KMT2AMEN1 | |
| SCHEMBL2348873 | 0.77 | KDM4E (0.52) | KDM4ELMNACYP1A2POLBMAPT | |
| SCHEMBL8518595 | 0.74 | DHODH (0.45) | KDM4ECCR1CCR5CCR8LMNA | |
| SCHEMBL8396868 | 0.73 | AXL (0.47) | KDM4EPOLBMAPTKMT2ATDP1 | |
| SCHEMBL8602462 | 0.73 | KDM4E (0.47) | KDM4ENPC1CCR1CCR5CCR8 | |
| SCHEMBL31199032 | 0.73 | KDM4E (0.55) | KDM4ENPC1CCR1CCR5CCR8 | |
| SCHEMBL19961977 | 0.73 | KDM4E (0.55) | KDM4ENPC1CCR1CCR5CCR8 | |
| SCHEMBL10961048 | 0.73 | KDM4E (0.59) | KDM4ENPC1CCR1CCR5CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638018-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | Cellzome Limited (GB) | 2013-09-18 | — | — | EP | disclosed |
| CN-103298794-A | Pyridine compounds and aza analogues thereof as TYK2 inhibitors | CELLZOME LTD | 2013-09-11 | — | — | CN | disclosed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | disclosed |