Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | KDM6B | O15054 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | KDM5C | P41229 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.43 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 2/20 | 0.40 |
| ▸ | CCR5 | P51681 | 2/20 | 0.40 |
| ▸ | CCR8 | P51685 | 2/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.40 |
| ▸ | XPO1 | O14980 | 1/20 | 0.40 |
| ▸ | JUN | P05412 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8396868 | 0.83 | AXL (0.47) | KDM4ETDP1KMT2APOLB | |
| SCHEMBL8394975 | 0.81 | JUN (0.55) | DHODHLMNASMN1; SMN2KDM4ETDP1 | |
| SCHEMBL2353404 | 0.78 | DHODH (0.42) | DHODHLMNAKDM4EKDM6BKDM4A | |
| SCHEMBL5189312 | 0.77 | CNR1 (0.48) | DHODHKDM4EKMT2APKMXPO1 | |
| SCHEMBL9688201 | 0.76 | CCR1 (0.46) | LMNASMN1; SMN2KDM4ETDP1PKM | |
| SCHEMBL8518593 | 0.75 | ALDH1A1 (0.49) | DHODHLMNASMN1; SMN2KDM4ETDP1 | |
| SCHEMBL4540085 | 0.74 | KDM4E (0.54) | LMNASMN1; SMN2KDM4ETDP1KMT2A | |
| SCHEMBL8394962 | 0.74 | KDM4E (0.44) | DHODHLMNASMN1; SMN2KDM4EKDM6B | |
| SCHEMBL17964400 | 0.74 | ALDH1A1 (0.55) | DHODHLMNASMN1; SMN2KDM4EKDM6B | |
| SCHEMBL1539362 | 0.74 | KDM4E (0.44) | DHODHLMNASMN1; SMN2KDM4EKDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5935966-A | COMPOUNDS THAT BLOCK THE ACTIVATION OF TRANSCRIPTION FACTORS THROUGH INHIBITION OF A FAMILY OF SPECIFIC KINASES, DECREASING PROINFLAMMATORY PROTEINS TO TREAT AUTOIMMUNE DISEASES AND AS GENERAL ANTIINFLAMMATORY AGENTS | SIGNAL PHARMACEUTICALS, INC. (US) | 1999-08-10 | — | — | US | disclosed |