Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4538521 | 0.83 | MAPT (0.35) | MAPTNPSR1MEN1KMT2AL3MBTL1 | |
| SCHEMBL4542974 | 0.80 | NPC1 (0.52) | MAPTNPSR1MEN1KMT2AL3MBTL1 | |
| SCHEMBL4540543 | 0.79 | MAPT (0.66) | MAPTNPSR1MEN1KMT2AL3MBTL1 | |
| SCHEMBL4538104 | 0.75 | MAPT (0.51) | MAPTNPSR1MEN1KMT2AALDH1A1 | |
| SCHEMBL4540710 | 0.74 | MAPT (0.54) | MAPTNPSR1MEN1KMT2AL3MBTL1 | |
| SCHEMBL4542232 | 0.74 | MEN1 (0.52) | MAPTNPSR1MEN1KMT2AALDH1A1 | |
| SCHEMBL951639 | 0.74 | MALT1 (0.38) | SMN1; SMN2CYP2C9LMNA | |
| SCHEMBL4538115 | 0.73 | NPC1 (0.48) | MAPTNPSR1MEN1KMT2AL3MBTL1 | |
| SCHEMBL10700256 | 0.72 | ALDH1A1 (0.50) | MAPTNPSR1MEN1KMT2AALDH1A1 | |
| SCHEMBL5858296 | 0.72 | ALDH1A1 (0.52) | MAPTNPSR1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |