Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Pentapiperium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 12/20 | 0.64 |
| ▸ | CHRM2 known ✓ | P08172 | 8/20 | 0.64 |
| ▸ | CHRM1 known ✓ | P11229 | 7/20 | 0.64 |
| ▸ | CHRM4 known ✓ | P08173 | 6/20 | 0.64 |
| ▸ | CHRM5 known ✓ | P08912 | 5/20 | 0.64 |
| ▸ | BLM | P54132 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | THRB | P10828 | 2/20 | 0.64 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | MTOR | P42345 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pentapiperium SCHEMBL1222217 | 0.99 | CHRM3 (0.66) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Pentapiperium SCHEMBL635862 | 0.91 | CHRM3 (0.57) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Bromide SCHEMBL14237580 | 0.85 | CHRM3 (0.51) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Pentapiperide SCHEMBL25997 | 0.81 | MEN1 (0.51) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL2730650 | 0.79 | CHRM3 (1.00) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Iodide SCHEMBL3987354 | 0.78 | CHRM3 (1.00) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL1222305 | 0.76 | CHRM2 (0.64) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL2990935 | 0.72 | CHRM3 (0.67) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL4964029 | 0.72 | KMT2A (0.70) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL19850893 | 0.71 | CHRM3 (0.66) | CHRM3CHRM2CHRM1CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2670490-B1 | SKIN DEODORIZING FILM | BEIERSDORF AG (DE) | 2018-06-27 | — | — | EP | disclosed |
| EP-2613758-B1 | MACROEMULSIONS WITH IMPROVED DEODORANT EFFICACY | BEIERSDORF AG (DE) | 2016-11-16 | — | — | EP | disclosed |
| US-8633225-B2 | Piperidinium compounds and cosmetic compositions containing them | BEIERSDORF AG (DE) | 2014-01-21 | — | — | US | disclosed |
| EP-2032118-B1 | COSMETIC COMPOSITIONS CONTAINING PIPERIDINIUM COMPOUNDS | BEIERSDORF AG (DE) | 2012-12-19 | — | — | EP | disclosed |
| WO-2012031987-A2 | OCTENIDINE DIHYDROCHLORIDE AS CO-EMULSIFIER IN MICROEMULSIONS | BEIERSDORF AG (DE) | 2012-03-15 | — | — | WO | disclosed |
| US-20110044923-A1 | PIPERIDINIUM COMPOUNDS AND COSMETIC COMPOSITIONS CONTAINING THEM | BEIERSDORF AG (DE) | 2011-02-24 | — | — | US | disclosed |
| US-7851633-B2 | Piperidinium compounds and cosmetic compositions containing them | BEIERSDORF AG (DE) | 2010-12-14 | — | — | US | disclosed |
| US-20070292375-A1 | Piperidinium compounds and cosmetic compositions containing them | BEIERSDORF AG (DE) | 2007-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070292375-A1 | Piperidinium compounds and cosmetic compositions containing them | CUTA, DPM1, TRPA1 | CHRM3 2445/4885CHRM2 1587/4885CHRM1 1184/4885 |
| US-20110044923-A1 | PIPERIDINIUM COMPOUNDS AND COSMETIC COMPOSITIONS CONTAINING THEM | CUTA, DPM1, TRPA1 | CHRM3 2445/4885CHRM2 1587/4885CHRM1 1184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.