Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 5/20 | 0.68 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4536444 | 0.85 | FASN (0.93) | FASNCHRM5KDM2BHTR7HTR6 | |
| SCHEMBL22259568 | 0.84 | FASN (0.59) | FASNCHRM5KDM2BHTR7HTR6 | |
| SCHEMBL4541971 | 0.81 | FASN (1.00) | FASNCHRM5HTR7HTR6MEN1 | |
| SCHEMBL30552767 | 0.81 | FASN (1.00) | FASNCHRM5HTR7HTR6MEN1 | |
| SCHEMBL4539747 | 0.79 | FASN (0.89) | FASNCHRM5HTR7HTR6MEN1 | |
| SCHEMBL4542033 | 0.78 | FASN (0.77) | FASNCHRM5HTR7HTR6MEN1 | |
| SCHEMBL4537573 | 0.77 | FASN (0.74) | FASNCHRM5HTR7HTR6MEN1 | |
| SCHEMBL4536291 | 0.76 | MGLL (0.48) | FASNKDM2BMEN1KMT2AALDH1A1 | |
| SCHEMBL15238380 | 0.76 | FASN (0.73) | FASNCHRM5HTR7HTR6MEN1 | |
| SCHEMBL4540768 | 0.76 | FASN (0.71) | FASNCHRM5HTR7HTR6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2637660-A1 | FATTY ACID SYNTHASE INHIBITORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2013-09-18 | — | — | EP | claimed |
| WO-2012064642-A1 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-05-18 | — | — | WO | claimed |
| EP-2637660-A1 | FATTY ACID SYNTHASE INHIBITORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012064642-A1 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-05-18 | — | — | WO | disclosed |