Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | FASN | P49327 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 3/20 | 0.42 |
| ▸ | EBP | Q15125 | 1/20 | 0.41 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.41 |
| ▸ | PKLR | P30613 | 1/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4541301 | 0.81 | FASN (0.68) | MGLLKDM4EL3MBTL1FASNGAA | |
| SCHEMBL25372233 | 0.77 | SMN1; SMN2 (0.48) | MGLLKDM4EL3MBTL1GAAALDH1A1 | |
| SCHEMBL4540780 | 0.76 | FASN (0.68) | KDM4EL3MBTL1FASNALDH1A1SMN1; SMN2 | |
| SCHEMBL26025565 | 0.74 | PKM (0.49) | KDM4EL3MBTL1GAAALDH1A1CYP2D6 | |
| SCHEMBL4538282 | 0.73 | FASN (0.76) | MGLLL3MBTL1FASNALDH1A1SMN1; SMN2 | |
| SCHEMBL18418150 | 0.72 | MGLL (0.59) | MGLLKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL18446300 | 0.71 | MGLL (0.70) | MGLLL3MBTL1ALDH1A1MEN1MAPK1 | |
| SCHEMBL4540739 | 0.71 | CNR1 (0.38) | KDM4EL3MBTL1FASNALDH1A1PKM | |
| SCHEMBL26025709 | 0.70 | PKM (0.50) | KDM4EL3MBTL1GAAALDH1A1CYP2D6 | |
| SCHEMBL25369903 | 0.70 | MGLL (0.41) | MGLLKDM4EL3MBTL1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2637660-A1 | FATTY ACID SYNTHASE INHIBITORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2013-09-18 | — | — | EP | claimed |
| WO-2012064642-A1 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-05-18 | — | — | WO | claimed |
| EP-2637660-A1 | FATTY ACID SYNTHASE INHIBITORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012064642-A1 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-05-18 | — | — | WO | disclosed |