Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HMGCR | P04035 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL42929 | 0.85 | ALDH1A1 (0.38) | ALDH1A1TSHRFFAR3MEN1CYP1A2 | |
| SCHEMBL938483 | 0.85 | ALDH1A1 (0.38) | ALDH1A1TSHRFFAR3MEN1CYP1A2 | |
| SCHEMBL2505815 | 0.85 | ALDH1A1 (0.38) | ALDH1A1TSHRFFAR3MEN1CYP1A2 | |
| SCHEMBL4845531 | 0.81 | TET2 (0.37) | ALDH1A1TSHRFFAR3MEN1CYP1A2 | |
| SCHEMBL27686063 | 0.81 | ALDH1A1 (0.35) | ALDH1A1TSHRFFAR3MEN1CYP1A2 | |
| SCHEMBL4845519 | 0.81 | TET2 (0.37) | ALDH1A1TSHRFFAR3MEN1CYP1A2 | |
| SCHEMBL458918 | 0.79 | GLRA1 (0.35) | ALDH1A1TSHRMEN1CYP1A2KMT2A | |
| SCHEMBL9495447 | 0.79 | TET2 (0.40) | ALDH1A1TSHRMEN1CYP1A2KMT2A | |
| SCHEMBL8517735 | 0.79 | ALDH1A1 (0.34) | ALDH1A1TSHRMEN1CYP1A2KMT2A | |
| SCHEMBL28334008 | 0.79 | ALDH1A1 (0.33) | ALDH1A1TSHRMEN1CYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150072939-A1 | LISURID, TERGURIDE AND DERIVATIVES THEREOF FOR USE IN THE PROPHYLAXIS AND/OR TREATMENT OF FIBROTIC CHANGES | SINOXA PHARMA GMBH (DE) | 2015-03-12 | — | — | US | disclosed |
| US-20140058108-A1 | Lisuride, Terguride and Derivatives Thereof for Use in the Prophylaxis and/or Treatment of Fibrotic Changes | SINOXA PHARMA UG (DE) | 2014-02-27 | — | — | US | disclosed |
| EP-2637644-A1 | LISURIDE, TERGURIDE AND DERIVATIVES THEREOF FOR USE IN THE PROPHYLAXIS AND/OR TREATMENT OF FIBROTIC CHANGES | Sinoxa Pharma UG (DE) | 2013-09-18 | — | — | EP | disclosed |
| EP-2550959-A1 | Lisuride, terguride and derivatives of same for use in the prevention and/or treatment of fibrotic changes | Sinoxa Pharma (DE) | 2013-01-30 | — | — | EP | disclosed |
| WO-2012062676-A1 | LISURIDE, TERGURIDE AND DERIVATIVES THEREOF FOR USE IN THE PROPHYLAXIS AND/OR TREATMENT OF FIBROTIC CHANGES | SINOXA PHARMA UG (DE) | 2012-05-18 | — | — | WO | disclosed |
| CN-101035931-A | Electrolyte solution, method for forming oxide film using the same, laminate, method for producing the laminate, and metal oxide film | MITSUBISHI CHEM CORP (JP) | 2007-09-12 | — | — | CN | disclosed |
| CN-1130255-C | Method for production of oxide catalyst for oxidation or ammoxidation | ASAHI KASEI CO LTD (JP) | 2003-12-10 | — | — | CN | disclosed |
| EP-0972776-B1 | A phosphine sulfide, a manufacturing process therefor and a use thereof | MITSUI CHEMICALS INC (JP) | 2003-04-23 | — | — | EP | disclosed |
| CN-1344584-A | Method for production of oxide catalyst for oxidation or ammoxidation | ASAHI KASEI CO LTD (JP) | 2002-04-17 | — | — | CN | disclosed |
| US-6153794-A | Phosphine sulfide, a manufacturing process therefor and use thereof | MITSUI CHEMICALS, INC. (JP) | 2000-11-28 | — | — | US | disclosed |
| EP-0972776-A1 | A phosphine sulfide, a manufacturing process therefor and a use thereof | Mitsui Chemicals, Inc. (JP) | 2000-01-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140058108-A1 | Lisuride, Terguride and Derivatives Thereof for Use in the Prophylaxis and/or Treatment of Fibrotic Changes | HTR2B, HTR2A, HTR7 | ALDH1A1 323/4885TSHR 245/4885FFAR3 443/4885 |
| US-20150072939-A1 | LISURID, TERGURIDE AND DERIVATIVES THEREOF FOR USE IN THE PROPHYLAXIS AND/OR TREATMENT OF FIBROTIC CHANGES | HTR2B, HTR2A, HTR1D | ALDH1A1 283/4885TSHR 259/4885FFAR3 571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.