Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 3/20 | 0.39 |
| ▸ | AKT2 | P31751 | 2/20 | 0.39 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.39 |
| ▸ | CIT | O14578 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PRKCB | P05771 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | PRKACB | P22694 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.39 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4541109 | 0.88 | AKT1 (0.53) | AKT1AKT2AKT3CITROCK2 | |
| SCHEMBL4543991 | 0.85 | AKT1 (0.45) | AKT1AKT2AKT3CITROCK2 | |
| SCHEMBL3506813 | 0.84 | AKT1 (0.43) | AKT1AKT2AKT3CITROCK2 | |
| SCHEMBL3506810 | 0.84 | AKT1 (0.43) | AKT1AKT2AKT3CITROCK2 | |
| SCHEMBL1529533 | 0.84 | AKT3 (0.53) | AKT1AKT2AKT3CITROCK2 | |
| SCHEMBL4379140 | 0.83 | AKT1 (0.40) | AKT1AKT2AKT3CITROCK2 | |
| SCHEMBL4379890 | 0.82 | AKT1 (0.43) | AKT1AKT2AKT3EPHX2 | |
| SCHEMBL1529896 | 0.81 | AKT1 (0.41) | AKT1AKT2AKT3CITROCK2 | |
| SCHEMBL1529893 | 0.81 | AKT1 (0.41) | AKT1AKT2AKT3CITROCK2 | |
| SCHEMBL4553919 | 0.81 | AKT1 (0.38) | AKT1P2RX7MAPK1SCN9ASCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117523-A1 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008098104-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |