Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | AKT2 | P31751 | 1/20 | 0.43 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 10/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 11/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 7/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4376050 | 0.91 | AKT1 (0.44) | AKT1AKT2AKT3PPARGPPARA | |
| SCHEMBL4380031 | 0.86 | AKT1 (0.39) | AKT1AKT2AKT3MCL1 | |
| SCHEMBL4373621 | 0.86 | AKT1 (0.39) | AKT1AKT2AKT3MCL1 | |
| SCHEMBL4543991 | 0.85 | AKT1 (0.45) | AKT1AKT2AKT3EPHX2 | |
| SCHEMBL4380618 | 0.84 | ALDH1A1 (0.41) | AKT1AKT2AKT3PPARGPPARA | |
| SCHEMBL4541109 | 0.82 | AKT1 (0.53) | AKT1AKT2AKT3MCL1 | |
| SCHEMBL4543363 | 0.82 | AKT1 (0.39) | AKT1AKT2AKT3EPHX2 | |
| SCHEMBL27770726 | 0.80 | AKT1 (0.46) | AKT1AKT2AKT3PPARGPPARA | |
| SCHEMBL3508879 | 0.80 | AKT1 (0.49) | AKT1AKT2AKT3PPARGPPARA | |
| SCHEMBL3508884 | 0.80 | AKT1 (0.49) | AKT1AKT2AKT3PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117523-A1 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008098104-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |