Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7301092 | 0.97 | CHRM2 (0.39) | CHRM2CHRM4CHRM5CHRM1ADRA2B | |
| SCHEMBL31352322 | 0.78 | CHRM2 (0.37) | CHRM2CHRM4CHRM5CHRM1ADRA2B | |
| Hydrochloric Acid SCHEMBL25366868 | 0.76 | CHRM2 (0.36) | CHRM2CHRM4CHRM5CHRM1SLC29A1 | |
| SCHEMBL9541697 | 0.74 | ALDH1A1 (0.36) | CHRM2CHRM4CHRM5CHRM1SLC29A1 | |
| SCHEMBL13419757 | 0.71 | CHRM2 (0.39) | CHRM2CHRM4CHRM5CHRM1ADRA2B | |
| SCHEMBL3922326 | 0.71 | CHRM2 (0.40) | CHRM2CHRM4CHRM5CHRM1ADRA2B | |
| SCHEMBL9201195 | 0.71 | CHRM2 (0.40) | CHRM2CHRM4CHRM5CHRM1ADRA2B | |
| SCHEMBL14640442 | 0.71 | CHRM2 (0.40) | CHRM2CHRM4CHRM5CHRM1ADRA2B | |
| SCHEMBL737055 | 0.71 | CHRM2 (0.40) | CHRM2CHRM4CHRM5CHRM1ADRA2B | |
| SCHEMBL5731686 | 0.71 | CHRM2 (0.40) | CHRM2CHRM4CHRM5CHRM1ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110128315-B | Compound, preparation method and application thereof, and glycosidase inhibitor | 中国科学院化学研究所 | 2021-08-20 | — | — | CN | disclosed |
| US-20170280643-A1 | Method of Improving the Growth and Production Output of Plants of the Family Solanaceae | ANKNER CHARLES E (US) | 2017-10-05 | — | — | US | disclosed |
| EP-1493744-B1 | Tropane analogs and methods for inhibition of monoamine transport | ORGANIX INC (US) | 2009-11-25 | — | — | EP | disclosed |
| US-20070244149-A1 | Tropane analogs and methods for inhibition of monoamine transport | ORGANIX, INC. (US) | 2007-10-18 | — | — | US | disclosed |
| US-7199132-B2 | Tropane analogs and methods for inhibition of monoamine transport | ORGANIX, INC. (US) | 2007-04-03 | — | — | US | disclosed |
| EP-1493744-A1 | Tropane analogs and methods for inhibition of monoamine transport | ORGANIX, INC. (US) | 2005-01-05 | — | — | EP | disclosed |
| EP-0996619-B1 | TROPANE ANALOGS AND METHODS FOR INHIBITION OF MONOAMINE TRANSPORT | ORGANIX INC (US) | 2005-01-05 | — | — | EP | disclosed |
| US-6670375-B2 | Particularly, 8-aza-, 8-carbo- and 8-oxo- tropanes having 6-or 7-substituents; preferred are the dopamine transporter, the serotonin transporter and the norepinephrine transporter. | ORGANIX, INC. | 2003-12-30 | — | — | US | disclosed |
| US-20030105125-A1 | Tropane analogs and methods for inhibition of monoamine transport | WILMINGTON TRUST (LONDON) LIMITED, AS SECURITY AGENT (GB) | 2003-06-05 | — | — | US | disclosed |
| US-20030069269-A1 | Tropane analogs and methods for inhibition of monoamine | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-04-10 | — | — | US | disclosed |
| US-6417221-B1 | SEROTONIN REUPTAKE INHIBITORS OR ANTISEROTONIN AGENTS | ORGANIX, INC. | 2002-07-09 | — | — | US | disclosed |
| US-6353105-B1 | INHIBITORS OF 5-HYDROXY-TRYPTAMINE REUPTAKE OF A MONOAMINE TRANSPORTER; ANALOGS OF COCAINE; | ORGANIX, INC. | 2002-03-05 | — | — | US | disclosed |
| US-20020010207-A1 | Tropane analogs and methods for inhibition of monoamine transport | WILMINGTON TRUST (LONDON) LIMITED, AS SECURITY AGENT (GB) | 2002-01-24 | — | — | US | disclosed |
| EP-0996619-A1 | TROPANE ANALOGS AND METHODS FOR INHIBITION OF MONOAMINE TRANSPORT | ORGANIX, INC. (US) | 2000-05-03 | — | — | EP | disclosed |
| US-5948933-A | THERAPY FOR DRUG ABRUSE | ORGANIX, INC. (US) | 1999-09-07 | — | — | US | disclosed |
| WO-1999002526-A1 | TROPANE ANALOGS AND METHODS FOR INHIBITION OF MONOAMINE TRANSPORT | ORGANIX, INC. (US) | 1999-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069269-A1 | Tropane analogs and methods for inhibition of monoamine | SLC6A2, SLC6A4, SLC18A2 | CHRM2 343/4885CHRM4 321/4885CHRM5 177/4885 |
| US-20030105125-A1 | Tropane analogs and methods for inhibition of monoamine transport | SLC6A2, SLC6A4, SLC6A3 | CHRM2 428/4885CHRM4 369/4885CHRM5 226/4885 |
| US-20020010207-A1 | Tropane analogs and methods for inhibition of monoamine transport | SLC6A2, SLC6A4, SLC6A3 | CHRM2 405/4885CHRM4 375/4885CHRM5 222/4885 |
| US-20070244149-A1 | Tropane analogs and methods for inhibition of monoamine transport | SLC6A2, SLC6A4, SLC6A3 | CHRM2 428/4885CHRM4 369/4885CHRM5 226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.