SCHEMBL4542129

SCHEMBL4542129

O=c1c2ccccc2sc2c(OCCCCl)ccc(Cl)c12

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.41
NPC1 O15118 2/20 0.41
HPGD P15428 2/20 0.41
RAB9A P51151 2/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
MCL1 Q07820 1/20 0.39
MAOA P21397 7/20 0.38
MAOB P27338 7/20 0.38
KDM4E B2RXH2 2/20 0.38
MAPK1 P28482 1/20 0.36
GPR84 Q9NQS5 3/20 0.36
HCRTR1 O43613 2/20 0.34
ALDH1A1 P00352 2/20 0.34
LMNA P02545 1/20 0.34
POLB P06746 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
KMT2A Q03164 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4538122 0.90 NPC1 (0.40) MAPTNPC1HPGDRAB9ACYP1A2
SCHEMBL28557156 0.90 MAPT (0.42) MAPTNPC1HPGDRAB9ACYP1A2
SCHEMBL108341 0.89 MAPT (0.43) MAPTNPC1HPGDRAB9ACYP1A2
SCHEMBL29353913 0.89 MAPT (0.43) MAPTNPC1HPGDRAB9ACYP1A2
SCHEMBL13066138 0.89 MAPT (0.40) MAPTNPC1HPGDRAB9ACYP1A2
SCHEMBL29428465 0.89 MAPT (0.43) MAPTNPC1HPGDRAB9ACYP1A2
SCHEMBL15392144 0.89 MAPT (0.40) MAPTNPC1HPGDRAB9ACYP1A2
SCHEMBL3159488 0.88 CYP2C9 (0.41) MAPTNPC1HPGDRAB9ACYP1A2
SCHEMBL1615173 0.88 CYP2C9 (0.41) MAPTNPC1HPGDRAB9ACYP1A2
SCHEMBL14556883 0.86 MAPT (0.45) MAPTNPC1HPGDRAB9ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3369751-A1 NOVEL PHOTOINITIATORS Coloplast A/S (DK) 2018-09-05 EP disclosed
US-10040893-B2 Polymeric photoinitiators and photoinitiator monomers COLOPLAST A/S (DK) 2018-08-07 US disclosed
EP-2638076-B1 NOVEL PHOTOINITIATORS COLOPLAST AS (DK) 2018-03-28 EP disclosed
EP-2850113-B1 NOVEL POLYMERIC PHOTOINITIATORS AND PHOTOINITIATOR MONOMERS COLOPLAST AS (DK) 2017-08-09 EP disclosed
US-9708425-B2 Routes to polyacrylates COLOPLAST A/S (DK) 2017-07-18 US disclosed
US-9670373-B2 Polymers comprising photoinitiator moieties and dye moieties LAMBSON LIMITED (GB) 2017-06-06 US disclosed
US-9399633-B2 Photoinitiators COLOPLAST A/S (DK) 2016-07-26 US disclosed
US-9371308-B2 Polymeric photoinitiators COLOPLAST A/S (DK) 2016-06-21 US disclosed
US-20160060243-A1 NOVEL PHOTOINITIATORS COLOPLAST A/S (DK) 2016-03-03 US disclosed
US-9212160-B2 Photoinitiators COLOPLAST A/S (DK) 2015-12-15 US disclosed
EP-2638076-A2 NOVEL PHOTOINITIATORS Coloplast A/S (DK) 2013-09-18 EP disclosed
EP-2638077-A1 NOVEL POLYMERIC PHOTOINITIATORS Coloplast A/S (DK) 2013-09-18 EP disclosed
EP-2638078-A1 NEW ROUTES TO POLYACRYLATES Coloplast A/S (DK) 2013-09-18 EP disclosed
CN-103221436-A New routes to polyacrylates COLOPLAST AS 2013-07-24 CN disclosed
CN-103201295-A Novel polymeric photoinitiators COLOPLAST AS 2013-07-10 CN disclosed
CN-103201296-A Novel photoinitiators COLOPLAST AS 2013-07-10 CN disclosed
WO-2013026451-A1 POLYMERS COMPRISING PHOTOINITIATOR MOIETIES AND DYE MOIETIES COLOPLAST A/S (DK) 2013-02-28 WO disclosed
WO-2012062333-A1 NOVEL POLYMERIC PHOTOINITIATORS COLOPLAST A/S (DK) 2012-05-18 WO disclosed
WO-2012062332-A2 NOVEL PHOTOINITIATORS COLOPLAST A/S (DK) 2012-05-18 WO disclosed
WO-2012062334-A1 NEW ROUTES TO POLYACRYLATES COLOPLAST A/S (DK) 2012-05-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160060243-A1 NOVEL PHOTOINITIATORS UROD, PUF60, PPOX MAPT 35/4885NPC1 4353/4885HPGD 719/4885
US-10040893-B2 Polymeric photoinitiators and photoinitiator monomers ACMSD, AAAS, PPOX MAPT 91/4885NPC1 4505/4885HPGD 2444/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.