Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542420 | 1.00 | KMT2A (0.48) | KMT2AHDAC3HDAC11HDAC8HDAC6 | |
| SCHEMBL13956734 | 0.84 | TSHR (0.56) | KMT2AMITFKLF5MEN1 | |
| SCHEMBL8202382 | 0.76 | RECQL (0.50) | HDAC3HDAC11HDAC8HDAC6DEGS1 | |
| SCHEMBL14095951 | 0.75 | RAB9A (0.72) | KMT2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL14521756 | 0.74 | HDAC3 (0.56) | KMT2AHDAC3HDAC11HDAC8HDAC6 | |
| SCHEMBL4361375 | 0.73 | HPGD (0.60) | KMT2ARAB9ANPC1MITFKLF5 | |
| SCHEMBL14095958 | 0.72 | HPGD (0.51) | KMT2AHDAC3HDAC11HDAC8HDAC6 | |
| SCHEMBL3822159 | 0.72 | SLC18A3 (0.67) | KMT2AHDAC3HDAC11HDAC8HDAC6 | |
| SCHEMBL13956735 | 0.70 | POLB (0.51) | RAB9ANPC1MITFKLF5LMNA | |
| SCHEMBL15157030 | 0.70 | SLC18A3 (0.68) | KMT2AHDAC3HDAC11HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7476686-B2 | Substituted aryl thioureas and related compounds; inhibitors of viral replication | ACHILLION PHARMACEUTICALS, INC. (US) | 2009-01-13 | — | — | US | disclosed |