Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 10/20 | 0.69 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.69 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | HPGD | P15428 | 4/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.69 |
| ▸ | GLA | P06280 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | TSHR | P16473 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10747983 | 0.86 | ADORA2B (0.70) | ADORA2BADORA2AADORA3KDM4EALDH1A1 | |
| SCHEMBL14564545 | 0.84 | ADORA2B (0.67) | ADORA2BADORA2AADORA3KDM4EALDH1A1 | |
| SCHEMBL3435824 | 0.83 | ADORA2B (0.80) | ADORA2BADORA2AADORA3KDM4EALDH1A1 | |
| SCHEMBL10806138 | 0.83 | ADORA2B (0.81) | ADORA2BADORA2AADORA3KDM4EALDH1A1 | |
| SCHEMBL1321892 | 0.82 | ADORA2B (1.00) | ADORA2BADORA2AADORA3KDM4EALDH1A1 | |
| SCHEMBL10807027 | 0.82 | ADORA2B (0.79) | ADORA2BADORA2AADORA3KDM4EALDH1A1 | |
| SCHEMBL10806711 | 0.81 | ADORA2B (0.98) | ADORA2BADORA2AADORA3KDM4EALDH1A1 | |
| SCHEMBL14129146 | 0.79 | ADORA2B (0.94) | ADORA2BADORA2AADORA3KDM4EALDH1A1 | |
| SCHEMBL10627309 | 0.79 | ADORA1 (0.68) | ADORA2BADORA2AADORA3ADORA1 | |
| Hydrochloric Acid SCHEMBL10631345 | 0.78 | ADORA1 (0.67) | ADORA2BADORA2AADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4772607-A | ALZHEIMER*S DISEASE, CNS STIMULANT, ANTIFIBRILLATORY, BRONCHODILATOR | WARNER-LAMBERT COMPANY (US) | 1988-09-20 | — | — | US | claimed |
| US-8871751-B2 | Compositions and methods relating to nuclear hormone and steroid hormone receptors including inhibitors of estrogen receptor alpha-mediated gene expression and inhibition of breast cancer | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2014-10-28 | — | — | US | disclosed |
| US-20090291972-A1 | Compositions and Methods Relating to Nuclear Hormone and Steroid Hormone Receptors Including Inhibitors of Estrogen Receptor Alpha-mediated Gene Expression and Inhibition of Breast Cancer | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2009-11-26 | — | — | US | disclosed |
| WO-1999031101-A1 | ADENOSINE RECEPTOR ANTAGONISTS WITH IMPROVED BIOACTIVITY | UNIVERSITY OF SOUTH FLORIDA (US) | 1999-06-24 | — | — | WO | disclosed |
| US-4772607-A | ALZHEIMER*S DISEASE, CNS STIMULANT, ANTIFIBRILLATORY, BRONCHODILATOR | WARNER-LAMBERT COMPANY (US) | 1988-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291972-A1 | Compositions and Methods Relating to Nuclear Hormone and Steroid Hormone Receptors Including Inhibitors of Estrogen Receptor Alpha-mediated Gene Expression and Inhibition of Breast Cancer | PGR, ESR1, CYP19A1 | ADORA2B 486/4885ADORA2A 566/4885ADORA3 781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.