Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CXCR4 | P61073 | 5/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29823635 | 0.99 | L3MBTL1 (0.43) | L3MBTL1ALDH1A1CXCR4CYP3A4CYP2D6 | |
| SCHEMBL1880250 | 0.99 | L3MBTL1 (0.43) | L3MBTL1ALDH1A1CXCR4CYP3A4CYP2D6 | |
| Bromide SCHEMBL4542897 | 0.88 | KDM4E (0.53) | L3MBTL1ALDH1A1CXCR4CYP3A4CYP2D6 | |
| SCHEMBL1870578 | 0.86 | KDM4E (0.53) | L3MBTL1ALDH1A1CXCR4CYP3A4CYP2D6 | |
| SCHEMBL29823129 | 0.86 | KDM4E (0.53) | L3MBTL1ALDH1A1CXCR4CYP3A4CYP2D6 | |
| Bromide SCHEMBL4543315 | 0.82 | HDAC1 (0.61) | L3MBTL1ALDH1A1CXCR4CYP3A4CYP2D6 | |
| SCHEMBL1882612 | 0.81 | HDAC1 (0.62) | L3MBTL1ALDH1A1CXCR4CYP3A4CYP2D6 | |
| SCHEMBL29823139 | 0.81 | HDAC1 (0.62) | L3MBTL1ALDH1A1CXCR4CYP3A4CYP2D6 | |
| Bromide SCHEMBL4550638 | 0.80 | HDAC1 (0.58) | L3MBTL1ALDH1A1CXCR4CYP3A4CYP2D6 | |
| SCHEMBL29823178 | 0.79 | HDAC1 (0.59) | L3MBTL1ALDH1A1CXCR4CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7629337-B2 | Chemokine receptor binding heterocyclic compounds | GENZYME CORPORATION (US) | 2009-12-08 | — | — | US | disclosed |
| US-20060264434-A1 | Chemokine receptor binding heterocyclic compounds | ANORMED INC. (CA) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264434-A1 | Chemokine receptor binding heterocyclic compounds | CCR5, CXCR4, CXCR1 | ACHE 4702/4885L3MBTL1 2574/4885ALDH1A1 1458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.