Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.48 |
| ▸ | CDC7 | O00311 | 9/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.40 |
| ▸ | PIM1 | P11309 | 5/20 | 0.40 |
| ▸ | GSK3B | P49841 | 5/20 | 0.40 |
| ▸ | CDK2 | P24941 | 4/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.40 |
| ▸ | MELK | Q14680 | 3/20 | 0.40 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.40 |
| ▸ | NEK2 | P51955 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.40 |
| ▸ | FYN | P06241 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4562750 | 0.82 | CAMKK2 (0.46) | CAMKK2CDC7DBF4JAK3CLK4 | |
| SCHEMBL4562747 | 0.76 | DYRK1A (0.41) | CAMKK2CDC7CLK4PIM1GSK3B | |
| SCHEMBL4562749 | 0.75 | CAMKK2 (0.46) | CAMKK2CDC7DBF4JAK3CLK4 | |
| SCHEMBL4562597 | 0.72 | TGFBR1 (0.48) | CAMKK2CDC7DBF4JAK3CLK4 | |
| SCHEMBL3740263 | 0.68 | CAMKK2 (0.69) | CAMKK2CDC7DBF4JAK3CLK4 | |
| SCHEMBL4562746 | 0.68 | DYRK1A (0.41) | CAMKK2CDC7JAK3CLK4PIM1 | |
| SCHEMBL8939866 | 0.67 | CAMKK2 (0.76) | CAMKK2CDC7JAK3CLK4PIM1 | |
| SCHEMBL8939859 | 0.67 | CAMKK2 (1.00) | CAMKK2CDC7JAK3CLK4PIM1 | |
| SCHEMBL4557411 | 0.66 | MAPT (0.42) | PIM1CDK2PRKD3ABL1CDK1 | |
| SCHEMBL858985 | 0.66 | CAMKK2 (0.70) | CAMKK2CDC7DBF4JAK3CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090298820-A1 | 3-SUBSTITUTED-1H-PYRROLO[2,3-B]PYRIDINE AND 3-SUBSTITUTED-1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH (US) | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298820-A1 | 3-SUBSTITUTED-1H-PYRROLO[2,3-B]PYRIDINE AND 3-SUBSTITUTED-1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | MTOR, PIK3CA, PIK3C2B | CAMKK2 207/4885CDC7 606/4885DBF4 4388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.