Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 8/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.41 |
| ▸ | SPR | P35270 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.35 |
| ▸ | SELE | P16581 | 1/20 | 0.35 |
| ▸ | WEE1 | P30291 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2688129 | 0.87 | KDM4E (0.43) | MTNR1BMTNR1ASPRKDM4EGAA | |
| SCHEMBL14502284 | 0.81 | MTNR1B (0.43) | MTNR1BMTNR1ASPRIDO1WEE1 | |
| SCHEMBL4092924 | 0.80 | IDO1 (0.58) | IDO1KDM4EGAALMNA | |
| SCHEMBL31693354 | 0.75 | KDM4E (0.45) | MTNR1BMTNR1ASPRKDM4ELMNA | |
| SCHEMBL18468650 | 0.74 | MTNR1B (0.48) | MTNR1BMTNR1ASPRGAALMNA | |
| SCHEMBL5121452 | 0.73 | SPR (0.50) | MTNR1BMTNR1ASPRKDM4EPLA2G2A | |
| SCHEMBL23809393 | 0.72 | KDM4E (0.46) | MTNR1BMTNR1AIDO1KDM4E | |
| SCHEMBL7241953 | 0.71 | KMT2A (0.48) | KDM4E | |
| SCHEMBL2007723 | 0.70 | KMT2A (0.55) | MTNR1BMTNR1ASPRGAALMNA | |
| SCHEMBL23672305 | 0.70 | MTNR1B (0.47) | MTNR1BMTNR1ASPRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638034-A1 | SUBSTITUTED HETEROAROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012062462-A1 | SUBSTITUTED HETEROAROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2012-05-18 | — | — | WO | disclosed |